This peptide is a ligand-gated channel that is activated by capsaicin, protons, and heat. Szallasi, A; Acta. Physiol. Scand. Supp., 629, 1, (1995); Caterina, MJ; et al., Nature, 398, 436, (1999); Michael, GJ; Priestle, JV., J. Neurosci., 19, 1844, (1999); Schumacher, MA; et al., J. Biol. Chem., 275, 2756, (2000); Savidge, J; et al., Neurosc., 102, 177, (2001); Kim, S; et al., J. Neurosci., 25, 662, (2005).
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