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Home » Peptide Synthesis Reagents » Alkenyl Building Blocks for Stapled Peptides

Alkenyl Building Blocks for Stapled Peptides

Stapled peptides are formed by incorporating special amino acids with olefinic side chains at the i and i+4 positions (one-loop staple) or at i and i+7 positions (two-loop staple). The hydrocarbon bridge is formed by a ring-closing metathesis reaction catalyzed by benzylidenebis(tricyclohexyl-phosphine)-dichlororuthenium (Grubb’s catalyst).

Stapled peptides are good drug leads due to these features:

• Retain active conformation
• Permeate cell membranes
• Resist proteolysis for longer duration

Stapled Peptide Literature
Molola, M; Memeo, MG; Quadrelli, P. Molecules, 2019, 24(20), 3654.

Achek, A; Shah, M; Seo, JY; et al. J. Med. Chem., 2019, 62(14), 6495-6511.

Maisel, SA; Broka, D; Atwell, B; et al. J. Transl. Med., 2019, 17(1), 201.

Showing 1–25 of 26 results

  • (R)-Fmoc-2-(3'-butenyl)glycine  [865352-21-2]
    Catalog #Product NameUnitPriceQty
    UFG202(R)-Fmoc-2-(3′-butenyl)glycine [865352-21-2]
    $395.00
  • (R)-Fmoc-2-(4'-pentenyl)glycine [1093645-21-6]
    Catalog #Product NameUnitPriceQty
    UFG203(R)-Fmoc-2-(4′-pentenyl)glycine [1093645-21-6]
    $185.00
  • (R)-Fmoc-2-(5'-hexenyl)glycine [1208226-88-3]
    Catalog #Product NameUnitPriceQty
    UFG205(R)-Fmoc-2-(5′-hexenyl)glycine [1208226-88-3]
    $580.00
  • (R)-Fmoc-2-(6'-heptenyl)glycine [1262886-63-4]
    Catalog #Product NameUnitPriceQty
    UFG206(R)-Fmoc-2-(6′-heptenyl)glycine [1262886-63-4]
    $575.00
  • (R)-Fmoc-2-(7'-octenyl)glycine [1191429-20-5]
    Catalog #Product NameUnitPriceQty
    UFG204(R)-Fmoc-2-(7′-octenyl)glycine [1191429-20-5]
    $525.00
  • (S)-Fmoc-2-(3'-butenyl)glycine [851909-08-5]
    Catalog #Product NameUnitPriceQty
    UFG102(S)-Fmoc-2-(3′-butenyl)glycine [851909-08-5]
    $765.00
  • (S)-Fmoc-2-(4'-pentenyl)glycine [856412-22-1]
    Catalog #Product NameUnitPriceQty
    UFG103(S)-Fmoc-2-(4′-pentenyl)glycine [856412-22-1]
    $300.00
  • (S)-Fmoc-2-(5'-hexenyl)glycine [1251904-51-4]
    Catalog #Product NameUnitPriceQty
    UFG105(S)-Fmoc-2-(5′-hexenyl)glycine [1251904-51-4]
    $325.00
  • (S)-Fmoc-2-(7'-octenyl)glycine [1262886-64-5]
    Catalog #Product NameUnitPriceQty
    UFG104(S)-Fmoc-2-(7′-octenyl)glycine [1262886-64-5]
    $250.00
  • (S)-N-Fmoc-2-(6'-heptenyl)glycine [1058705-57-9]
    Catalog #Product NameUnitPriceQty
    UFG106(S)-N-Fmoc-2-(6′-heptenyl)glycine [1058705-57-9]
    $700.00
  • Fmoc-(R)-2-(2-propenyl)alanine [288617-76-5]
    Catalog #Product NameUnitPriceQty
    UFA220Fmoc-(R)-2-(2-propenyl)alanine [288617-76-5]
    $260.00
  • Fmoc-(R)-2-(3-butenyl)alanine [1311933-82-0]
    Catalog #Product NameUnitPriceQty
    UFA223Fmoc-(R)-2-(3-butenyl)alanine [1311933-82-0]
    $470.00
  • Fmoc-(R)-2-(4-pentenyl)alanine [288617-77-6]
    Catalog #Product NameUnitPriceQty
    UFA221Fmoc-(R)-2-(4-pentenyl)alanine [288617-77-6]
    $295.00
  • Fmoc-(R)-2-(5-hexenyl)alanine [288617-78-7]
    Catalog #Product NameUnitPriceQty
    UFA224Fmoc-(R)-2-(5-hexenyl)alanine [288617-78-7]
    $250.00
  • Fmoc-(R)-2-(6-heptenyl)alanine [1311933-84-2]
    Catalog #Product NameUnitPriceQty
    UFA225Fmoc-(R)-2-(6-heptenyl)alanine [1311933-84-2]
    $495.00
  • Fmoc-(R)-2-(7-octenyl)alanine [945212-26-0]
    Catalog #Product NameUnitPriceQty
    UFA222Fmoc-(R)-2-(7-octenyl)alanine [945212-26-0]
    $295.00
  • Fmoc-(S)-2-(2-propenyl)alanine [288617-71-0]
    Catalog #Product NameUnitPriceQty
    UFA120Fmoc-(S)-2-(2-propenyl)alanine [288617-71-0]
    $320.00
  • Fmoc-(S)-2-(3-butenyl)alanine [288617-72-1]
    Catalog #Product NameUnitPriceQty
    UFA123Fmoc-(S)-2-(3-butenyl)alanine [288617-72-1]
    $635.00
  • Fmoc-(S)-2-(4-pentenyl)alanine [288617-73-2]
    Catalog #Product NameUnitPriceQty
    UFA121Fmoc-(S)-2-(4-pentenyl)alanine [288617-73-2]
    $295.00
  • Fmoc-(S)-2-(5-hexenyl)alanine [288617-74-3]
    Catalog #Product NameUnitPriceQty
    UFA124Fmoc-(S)-2-(5-hexenyl)alanine [288617-74-3]
    $495.00
  • Fmoc-(S)-2-(6-heptenyl)alanine [1311933-83-1]
    Catalog #Product NameUnitPriceQty
    UFA125Fmoc-(S)-2-(6-heptenyl)alanine [1311933-83-1]
    $495.00
  • Fmoc-(S)-2-(7-octenyl)alanine [288617-75-4]
    Catalog #Product NameUnitPriceQty
    UFA122Fmoc-(S)-2-(7-octenyl)alanine [288617-75-4]
    $295.00
  • Fmoc-2-amino-2-(pent-4-enyl)dec-9-enoic acid [1211504-14-1]
    Catalog #Product NameUnitPriceQty
    UFA028Fmoc-2-amino-2-(pent-4-enyl)dec-9-enoic acid [1211504-14-1]
    $350.00
  • Fmoc-2,2-bis(2-propenyl)glycine [1311992-97-8]
    Catalog #Product NameUnitPriceQty
    UFA023Fmoc-2,2-bis(2-propenyl)glycine [1311992-97-8]
    $495.00
  • Fmoc-2,2-bis(3-butenyl)glycine [1311992-98-9]
    Catalog #Product NameUnitPriceQty
    UFA024Fmoc-2,2-bis(3-butenyl)glycine [1311992-98-9]
    $130.00