Alkenyl Building Blocks for Stapled Peptides

Stapled peptides are formed by incorporating special amino acids with olefinic side chains at the i and i+4 positions (one-loop staple) or at i and i+7 positions (two-loop staple). The hydrocarbon bridge is formed by a ring-closing metathesis reaction catalyzed by benzylidenebis(tricyclohexyl-phosphine)-dichlororuthenium (Grubb’s catalyst).

Stapled peptides are good drug leads due to these features:

• Retain active conformation
• Permeate cell membranes
• Resist proteolysis for longer duration

Stapled Peptide Literature
Molola, M; Memeo, MG; Quadrelli, P. Molecules, 2019, 24(20), 3654.

Achek, A; Shah, M; Seo, JY; et al. J. Med. Chem., 2019, 62(14), 6495-6511.

Maisel, SA; Broka, D; Atwell, B; et al. J. Transl. Med., 2019, 17(1), 201.

Showing 1–25 of 26 results

Catalog # Product Name Unit Price Qty
UFG202 (R)-Fmoc-2-(3′-butenyl)glycine [865352-21-2]
$395.00
(R)-Fmoc-2-(3'-butenyl)glycine [865352-21-2] quantity
Catalog # Product Name Unit Price Qty
UFG203 (R)-Fmoc-2-(4′-pentenyl)glycine [1093645-21-6]
$185.00
(R)-Fmoc-2-(4'-pentenyl)glycine [1093645-21-6] quantity
Catalog # Product Name Unit Price Qty
UFG205 (R)-Fmoc-2-(5′-hexenyl)glycine [1208226-88-3]
$580.00
(R)-Fmoc-2-(5'-hexenyl)glycine [1208226-88-3] quantity
Catalog # Product Name Unit Price Qty
UFG206 (R)-Fmoc-2-(6′-heptenyl)glycine [1262886-63-4]
$575.00
(R)-Fmoc-2-(6'-heptenyl)glycine [1262886-63-4] quantity
Catalog # Product Name Unit Price Qty
UFG204 (R)-Fmoc-2-(7′-octenyl)glycine [1191429-20-5]
$525.00
(R)-Fmoc-2-(7'-octenyl)glycine [1191429-20-5] quantity
Catalog # Product Name Unit Price Qty
UFG102 (S)-Fmoc-2-(3′-butenyl)glycine [851909-08-5]
$765.00
(S)-Fmoc-2-(3'-butenyl)glycine [851909-08-5] quantity
Catalog # Product Name Unit Price Qty
UFG103 (S)-Fmoc-2-(4′-pentenyl)glycine [856412-22-1]
$300.00
(S)-Fmoc-2-(4'-pentenyl)glycine [856412-22-1] quantity
Catalog # Product Name Unit Price Qty
UFG105 (S)-Fmoc-2-(5′-hexenyl)glycine [1251904-51-4]
$325.00
(S)-Fmoc-2-(5'-hexenyl)glycine [1251904-51-4] quantity
Catalog # Product Name Unit Price Qty
UFG104 (S)-Fmoc-2-(7′-octenyl)glycine [1262886-64-5]
$250.00
(S)-Fmoc-2-(7'-octenyl)glycine [1262886-64-5] quantity
Catalog # Product Name Unit Price Qty
UFG106 (S)-N-Fmoc-2-(6′-heptenyl)glycine [1058705-57-9]
$700.00
(S)-N-Fmoc-2-(6'-heptenyl)glycine [1058705-57-9] quantity
Catalog # Product Name Unit Price Qty
UFA220 Fmoc-(R)-2-(2-propenyl)alanine [288617-76-5]
$260.00
Fmoc-(R)-2-(2-propenyl)alanine [288617-76-5] quantity
Catalog # Product Name Unit Price Qty
UFA223 Fmoc-(R)-2-(3-butenyl)alanine [1311933-82-0]
$470.00
Fmoc-(R)-2-(3-butenyl)alanine [1311933-82-0] quantity
Catalog # Product Name Unit Price Qty
UFA221 Fmoc-(R)-2-(4-pentenyl)alanine [288617-77-6]
$295.00
Fmoc-(R)-2-(4-pentenyl)alanine [288617-77-6] quantity
Catalog # Product Name Unit Price Qty
UFA224 Fmoc-(R)-2-(5-hexenyl)alanine [288617-78-7]
$250.00
Fmoc-(R)-2-(5-hexenyl)alanine [288617-78-7] quantity
Catalog # Product Name Unit Price Qty
UFA225 Fmoc-(R)-2-(6-heptenyl)alanine [1311933-84-2]
$495.00
Fmoc-(R)-2-(6-heptenyl)alanine [1311933-84-2] quantity
Catalog # Product Name Unit Price Qty
UFA222 Fmoc-(R)-2-(7-octenyl)alanine [945212-26-0]
$295.00
Fmoc-(R)-2-(7-octenyl)alanine [945212-26-0] quantity
Catalog # Product Name Unit Price Qty
UFA120 Fmoc-(S)-2-(2-propenyl)alanine [288617-71-0]
$320.00
Fmoc-(S)-2-(2-propenyl)alanine [288617-71-0] quantity
Catalog # Product Name Unit Price Qty
UFA123 Fmoc-(S)-2-(3-butenyl)alanine [288617-72-1]
$635.00
Fmoc-(S)-2-(3-butenyl)alanine [288617-72-1] quantity
Catalog # Product Name Unit Price Qty
UFA121 Fmoc-(S)-2-(4-pentenyl)alanine [288617-73-2]
$295.00
Fmoc-(S)-2-(4-pentenyl)alanine [288617-73-2] quantity
Catalog # Product Name Unit Price Qty
UFA124 Fmoc-(S)-2-(5-hexenyl)alanine [288617-74-3]
$495.00
Fmoc-(S)-2-(5-hexenyl)alanine [288617-74-3] quantity
Catalog # Product Name Unit Price Qty
UFA125 Fmoc-(S)-2-(6-heptenyl)alanine [1311933-83-1]
$495.00
Fmoc-(S)-2-(6-heptenyl)alanine [1311933-83-1] quantity
Catalog # Product Name Unit Price Qty
UFA122 Fmoc-(S)-2-(7-octenyl)alanine [288617-75-4]
$295.00
Fmoc-(S)-2-(7-octenyl)alanine [288617-75-4] quantity
Catalog # Product Name Unit Price Qty
UFA028 Fmoc-2-amino-2-(pent-4-enyl)dec-9-enoic acid [1211504-14-1]
$350.00
Fmoc-2-amino-2-(pent-4-enyl)dec-9-enoic acid [1211504-14-1] quantity
Catalog # Product Name Unit Price Qty
UFA023 Fmoc-2,2-bis(2-propenyl)glycine [1311992-97-8]
$495.00
Fmoc-2,2-bis(2-propenyl)glycine [1311992-97-8] quantity
Catalog # Product Name Unit Price Qty
UFA024 Fmoc-2,2-bis(3-butenyl)glycine [1311992-98-9]
$130.00
Fmoc-2,2-bis(3-butenyl)glycine [1311992-98-9] quantity