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Hmb and Dmb Dipeptides

Hmb and Dmb dipeptides disrupt hydrogen bonding in the peptide backbone and reduces aggregation. Incorporated into long or difficult peptides, N-Dmb dipeptides can improve peptide yield and purity. When the Dmb protecting group is attached to the amino acid preceding Asp in a peptide, Dmb blocks aspartimide formation and the side products resulting from aspartimide formation (Quibell, M.; et al. J. Chem. Soc., Chem. Commun. 1994, 2343-4). In SPPS the N-Dmb group is removed with TFA during peptide cleavage from the resin.

Guidelines for Using Hmb- or Dmb-Protected Amino Acids

1. If possible, the Hmb- or Dmb-protected amino acid should be inserted before hydrophobic regions.
2. There should be at least 2 amino acids between the Hmb- or Dmb-protected amino and other backbone H-bonding disrupters such as prolines, pseudoprolines or isoacyl dipeptides.
3. The optimum spacing between H-bond dirupting elements is 5-6 amino acids.

Showing all 14 results

  • Catalog #Product NameUnitPriceQty
    NDA101Fmoc-(Dmb)Ala-OH [1425938-66-4]
    $120.00
  • Fmoc-(Dmb)Gly-OH [166881-42-1]
    Catalog #Product NameUnitPriceQty
    NGG105Fmoc-(Dmb)Gly-OH [166881-42-1]
    $90.00
  • Fmoc-(FmocHmb)Ala-OH [148515-85-9]
    Catalog #Product NameUnitPriceQty
    NFA001Fmoc-(FmocHmb)Ala-OH [148515-85-9]
    $285.00
  • Fmoc-(FmocHmb)Gly-OH [148515-84-8]
    Catalog #Product NameUnitPriceQty
    NFG001Fmoc-(FmocHmb)Gly-OH [148515-84-8]
    $700.00
  • Fmoc-(FmocHmb)Lys(Boc)-OH
    Catalog #Product NameUnitPriceQty
    NFK001Fmoc-(FmocHmb)Lys(Boc)-OH
    $285.00
  • Fmoc-(FmocHmb)Phe-OH [148515-88-2]
    Catalog #Product NameUnitPriceQty
    NFF001Fmoc-(FmocHmb)Phe-OH [148515-88-2]
    $320.00
  • Fmoc-(FmocHmb)Val-OH [148515-86-0]
    Catalog #Product NameUnitPriceQty
    NFV001Fmoc-(FmocHmb)Val-OH [148515-86-0]
    $320.00
  • Fmoc-Ala-(Dmb)Gly-OH [1188402-17-6]
    Catalog #Product NameUnitPriceQty
    NGA101Fmoc-Ala-(Dmb)Gly-OH [1188402-17-6]
    $140.00
  • Fmoc-Asp(OtBu)-(Dmb)Gly-OH [900152-72-9]
    Catalog #Product NameUnitPriceQty
    NGD105Fmoc-Asp(OtBu)-(Dmb)Gly-OH [900152-72-9]
    $275.00
  • Catalog #Product NameUnitPriceQty
    NGG101Fmoc-Gly-(Dmb)Gly-OH [848861-65-4]
    $100.00
  • Fmoc-Ile-(Dmb)Gly-OH
    Catalog #Product NameUnitPriceQty
    NGI101Fmoc-Ile-(Dmb)Gly-OH
    $250.00
  • Fmoc-Leu-(Dmb)Gly-OH
    Catalog #Product NameUnitPriceQty
    NGL101Fmoc-Leu-(Dmb)Gly-OH
    $100.00
  • Fmoc-Pro-(Dmb)Gly-OH
    Catalog #Product NameUnitPriceQty
    NGP101Fmoc-Pro-(Dmb)Gly-OH
    $150.00
  • Fmoc-Val-(Dmb)Gly-OH
    Catalog #Product NameUnitPriceQty
    NGV101Fmoc-Val-(Dmb)Gly-OH
    $100.00