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Alkynyl Amino Acids

Alkynyl amino acids react with azides in a 1,3-cycloaddition reaction to form a 1,2,3-triazole. This is a convenient method of forming cyclic peptides or stapled peptides, or conjugating a peptide with a dye, radioactive tracer, antibody or complex biomolecule. These alkynyl amino acids can be utilized in solid phase peptide synthesizers or in solution phase synthesis.

Rashad A.A. (2019) Click Chemistry for Cyclic Peptide Drug Design. In: Goetz G. (eds) Cyclic Peptide Design. Methods in Molecular Biology, vol 2001. Humana, New York, NY, pp 133-145.

Wilder, LM; Fies, WA; Rabin, C; Webb, LJ; Crooks, RM. Langmuir, 2019, 35(9), 3363-3371.

Lee, DJ; Cameron, AJ; Wright, TH; Harris, PWR; Brimble, MA. Chem Sci., 2018, 10(3), 815-828.

Showing all 5 results

  • (R)-N-Fmoc-2-(2'-propynyl)alanine [1198791-65-9]
    Catalog # Product Name
    UFA240 (R)-N-Fmoc-2-(2′-propynyl)alanine [1198791-65-9] Please contact AAPPTec for a quotation.
  • (S)-N-Fmoc-2-(2'-propynyl)alanine [1198791-58-0]
    Catalog # Product Name Unit Price Qty
    UFA140 (S)-N-Fmoc-2-(2′-propynyl)alanine [1198791-58-0]
    $340.00
  • Fmoc-D-Pra-OH [220497-98-3]
    Catalog # Product Name Unit Price Qty
    UFG235 Fmoc-D-Pra-OH [220497-98-3]
    $110.00
  • Catalog # Product Name Unit Price Qty
    UFG115 Fmoc-HPra-OH [942518-21-0]
    $210.00
  • Fmoc-Pra-OH [198561-07-8]
    Catalog # Product Name Unit Price Qty
    UFG135 Fmoc-Pra-OH [198561-07-8]
    $115.00