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Alkynyl Amino Acids

Alkynyl amino acids react with azides in a 1,3-cycloaddition reaction to form a 1,2,3-triazole. This is a convenient method of forming cyclic peptides or stapled peptides, or conjugating a peptide with a dye, radioactive tracer, antibody or complex biomolecule. These alkynyl amino acids can be utilized in solid phase peptide synthesizers or in solution phase synthesis.

Rashad A.A. (2019) Click Chemistry for Cyclic Peptide Drug Design. In: Goetz G. (eds) Cyclic Peptide Design. Methods in Molecular Biology, vol 2001. Humana, New York, NY, pp 133-145.

Wilder, LM; Fies, WA; Rabin, C; Webb, LJ; Crooks, RM. Langmuir, 2019, 35(9), 3363-3371.

Lee, DJ; Cameron, AJ; Wright, TH; Harris, PWR; Brimble, MA. Chem Sci., 2018, 10(3), 815-828.

Showing all 5 results

  • (R)-N-Fmoc-2-(2'-propynyl)alanine [1198791-65-9]
    Catalog #Product NameUnitPriceQty
    UFA240(R)-N-Fmoc-2-(2′-propynyl)alanine [1198791-65-9]
  • (S)-N-Fmoc-2-(2'-propynyl)alanine [1198791-58-0]
    Catalog #Product NameUnitPriceQty
    UFA140(S)-N-Fmoc-2-(2′-propynyl)alanine [1198791-58-0]
  • Fmoc-D-Pra-OH [220497-98-3]
    Catalog #Product NameUnitPriceQty
    UFG235Fmoc-D-Pra-OH [220497-98-3]
  • Catalog #Product NameUnitPriceQty
    UFG115Fmoc-HPra-OH [942518-21-0]
  • Fmoc-Pra-OH [198561-07-8]
    Catalog #Product NameUnitPriceQty
    UFG135Fmoc-Pra-OH [198561-07-8]