Reagents Used in Peptide Synthesis

Peptide coupling reagents are used to form the amide bonds that link separate amino acids into peptides and proteins. Peptide coupling reagents are also used to connect Boc amino acid or Fmoc amino acids to peptide synthesis resins, connect peptide synthesis linker molecules to base resins, and to form ester bonds in depsipeptides. Peptide coupling reagents react with protected amino acids to form activated amino acid intermediates which in turn react with the N-terminal amine of the peptide to form the elongated peptide. Formation of the activated amino acid intermediate can cause partial racemization of the amino acid which introduces peptide impurities and reduces the yield of the desired peptide product. Peptide coupling additives are used with the peptide coupling reagents to suppress the racemization of the activated amino acid intermediate.

Common coupling reagents include:

Carbodiimides (DCC, DIC, EDC)
Triaminophosphonium compounds (BOP, PyBOP, PyBrOP)
Tetramethylaminium/Tetramethyluronium compounds (HATU, HBTU, HCTU, etc.)

AAPPTec provides the highest purity coupling reagents at very competitive prices.

Showing 1–25 of 45 results

Catalog # Product Name
CXX101 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline [16357-59-8] Please contact AAPPTec for a quotation.
Catalog # Product Name Unit Price Qty
CXZ096 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
$90.00
6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6] quantity
Catalog # Product Name Unit Price Qty
CXZ006 9-Fluorenyl-methanol [24324-17-2]
$140.00
9-Fluorenyl-methanol [24324-17-2] quantity
Catalog # Product Name Unit Price Qty
CXZ018 AMC, 7-Amino-4-methylcoumarin [26093-31-2]
$50.00
AMC, 7-Amino-4-methylcoumarin [26093-31-2] quantity
Catalog # Product Name Unit Price Qty
CXZ011 Boc Anhydride [24424-99-5]
$350.00
Boc Anhydride [24424-99-5] quantity
Catalog # Product Name Unit Price Qty
CXZ016 Boc-ON [58632-95-4]
$140.00
Boc-ON [58632-95-4] quantity
Catalog # Product Name Unit Price Qty
CXZ001 BOP Reagent [56602-33-6]
$45.00
BOP Reagent [56602-33-6] quantity
Catalog # Product Name Unit Price Qty
CXZ090 BOP-Cl [68641-49-6]
$90.00
BOP-Cl [68641-49-6] quantity
Catalog # Product Name Unit Price Qty
CXZ031 COMU [1075198-30-9]
$55.00
COMU [1075198-30-9] quantity
Catalog # Product Name Unit Price Qty
CXZ007 D-Biotin [58-85-5]
$40.00
D-Biotin [58-85-5] quantity
Catalog # Product Name Unit Price Qty
CXZ060 DEPBT [165534-43-0]
$120.00
DEPBT [165534-43-0] quantity
Catalog # Product Name Unit Price Qty
CXZ008 DMT-Cl [40615-36-9]
$60.00
DMT-Cl [40615-36-9] quantity
Catalog # Product Name Unit Price Qty
CXZ038 DOTA-Tris(tBu) [137076-54-1]
$150.00
DOTA-Tris(tBu) [137076-54-1] quantity
Catalog # Product Name Unit Price Qty
CXZ009 DSC [74124-79-1]
$140.00
DSC [74124-79-1] quantity
Catalog # Product Name Unit Price Qty
CXZ005 EDC HCl [25952-53-8]
$70.00
EDC HCl [25952-53-8] quantity
Catalog # Product Name Unit Price Qty
CXZ037 Fmoc-6-HNA [444794-69-8]
$250.00
Fmoc-6-HNA [444794-69-8] quantity
Catalog # Product Name Unit Price Qty
CXZ014 Fmoc-Cl [28920-43-6]
$50.00
Fmoc-Cl [28920-43-6] quantity
Catalog # Product Name Unit Price Qty
CXZ013 Fmoc-NH2 [84418-43-9]
$125.00
Fmoc-NH2 [84418-43-9] quantity
Catalog # Product Name Unit Price Qty
CXZ091 Fmoc-OSu [82911-69-1]
$25.00
Fmoc-OSu [82911-69-1] quantity
Catalog # Product Name
CXC001 Grubb’s Catalyst Please contact AAPPTec for a quotation.
Catalog # Product Name Unit Price Qty
CXZ025 HATU [148893-10-1]
$130.00
HATU [148893-10-1] quantity
Catalog # Product Name Unit Price Qty
CXZ020 HBTU [94790-37-1]
$68.00
HBTU [94790-37-1] quantity
Catalog # Product Name Unit Price Qty
CXZ030 HCTU [330645-87-9]
$55.00
HCTU [330645-87-9] quantity
Catalog # Product Name Unit Price Qty
CXZ012 HOAt [39968-33-7] 1-Hydroxy-7-azabenzotriazole
$40.00
HOAt [39968-33-7] 1-Hydroxy-7-azabenzotriazole quantity
Catalog # Product Name Unit Price Qty
CXZ010 HOBt H2O [123333-53-9]
$150.00
HOBt H2O [123333-53-9] quantity