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Home » Peptide Synthesis Reagents » Reagents Used in Peptide Synthesis

Reagents Used in Peptide Synthesis

Peptide coupling reagents are used to form the amide bonds that link separate amino acids into peptides and proteins. Peptide coupling reagents are also used to connect Boc amino acid or Fmoc amino acids to peptide synthesis resins, connect peptide synthesis linker molecules to base resins, and to form ester bonds in depsipeptides. Peptide coupling reagents react with protected amino acids to form activated amino acid intermediates which in turn react with the N-terminal amine of the peptide to form the elongated peptide. Formation of the activated amino acid intermediate can cause partial racemization of the amino acid which introduces peptide impurities and reduces the yield of the desired peptide product. Peptide coupling additives are used with the peptide coupling reagents to suppress the racemization of the activated amino acid intermediate.  

Common coupling reagents include:

Carbodiimides (DCC, DIC, EDC)
Triaminophosphonium compounds (BOP, PyBOP, PyBrOP)
Tetramethylaminium/Tetramethyluronium compounds (HATU, HBTU, HCTU, etc.)

AAPPTec provides the highest purity coupling reagents at very competitive prices.

Showing 1–25 of 46 results

  • Placeholder
    Catalog #Product Name
    CXX1012-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline [16357-59-8]Please contact AAPPTec for a quotation.
  • 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole  [26198-19-6]
    Catalog #Product NameUnitPriceQty
    CXZ0966-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
    $90.00
  • 9-Fluorenyl-methanol  [24324-17-2]
    Catalog #Product NameUnitPriceQty
    CXZ0069-Fluorenyl-methanol [24324-17-2]
    $140.00
  • AMC, 7-Amino-4-methylcoumarin [26093-31-2]
    Catalog #Product NameUnitPriceQty
    CXZ018AMC, 7-Amino-4-methylcoumarin [26093-31-2]
    $50.00
  • Catalog #Product NameUnitPriceQty
    CXZ011Boc Anhydride [24424-99-5]
    $350.00
  • Boc-ON  [58632-95-4]
    Catalog #Product NameUnitPriceQty
    CXZ016Boc-ON [58632-95-4]
    $140.00
  • BOP  [56602-33-6]
    Catalog #Product NameUnitPriceQty
    CXZ001BOP Reagent [56602-33-6]
    $45.00
  • BOP-Cl  [68641-49-6]
    Catalog #Product NameUnitPriceQty
    CXZ090BOP-Cl [68641-49-6]
    $90.00
  • COMU   [1075198-30-9]
    Catalog #Product NameUnitPriceQty
    CXZ031COMU [1075198-30-9]
    $55.00
  • Biotin  [58-85-5]
    Catalog #Product NameUnitPriceQty
    CXZ007D-Biotin [58-85-5]
    $40.00
  • DEPBT  [165534-43-0]
    Catalog #Product NameUnitPriceQty
    CXZ060DEPBT [165534-43-0]
    $120.00
  • DMT-Cl  [40615-36-9]
    Catalog #Product NameUnitPriceQty
    CXZ008DMT-Cl [40615-36-9]
    $60.00
  • DOTA-Tris(tBu) [137076-54-1]
    Catalog #Product NameUnitPriceQty
    CXZ038DOTA-Tris(tBu) [137076-54-1]
    $150.00
  • DSC  [74124-79-1]
    Catalog #Product NameUnitPriceQty
    CXZ009DSC [74124-79-1]
    $140.00
  • EDC HCl  [25952-53-8]
    Catalog #Product NameUnitPriceQty
    CXZ005EDC HCl [25952-53-8]
    $70.00
  • Fmoc-6-HNA  [444794-69-8]
    Catalog #Product NameUnitPriceQty
    CXZ037Fmoc-6-HNA [444794-69-8]
    $250.00
  • Fmoc-Cl  [28920-43-6]
    Catalog #Product NameUnitPriceQty
    CXZ014Fmoc-Cl [28920-43-6]
    $82.00
  • Fmoc-NH2  [84418-43-9]
    Catalog #Product NameUnitPriceQty
    CXZ013Fmoc-NH2 [84418-43-9]
    $125.00
  • Fmoc-OSu  [82911-69-1]
    Catalog #Product NameUnitPriceQty
    CXZ091Fmoc-OSu [82911-69-1]
    $25.00
  • Placeholder
    Catalog #Product Name
    CXC001Grubb’s CatalystPlease contact AAPPTec for a quotation.
  • HATU  [148893-10-1]
    Catalog #Product NameUnitPriceQty
    CXZ025HATU [148893-10-1]
    $130.00
  • HBTU  [94790-37-1]
    Catalog #Product NameUnitPriceQty
    CXZ020HBTU [94790-37-1]
    $68.00
  • HCTU  [330645-87-9]
    Catalog #Product NameUnitPriceQty
    CXZ030HCTU [330645-87-9]
    $55.00
  • HOAt  [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    Catalog #Product NameUnitPriceQty
    CXZ012HOAt [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    $40.00
  • HOBt  H2O   [123333-53-9]
    Catalog #Product NameUnitPriceQty
    CXZ010HOBt H2O [123333-53-9]
    $150.00