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Reagents Used in Peptide Synthesis

Peptide coupling reagents are used to form the amide bonds that link separate amino acids into peptides and proteins. Peptide coupling reagents are also used to connect Boc amino acid or Fmoc amino acids to peptide synthesis resins, connect peptide synthesis linker molecules to base resins, and to form ester bonds in depsipeptides. Peptide coupling reagents react with protected amino acids to form activated amino acid intermediates which in turn react with the N-terminal amine of the peptide to form the elongated peptide. Formation of the activated amino acid intermediate can cause partial racemization of the amino acid which introduces peptide impurities and reduces the yield of the desired peptide product. Peptide coupling additives are used with the peptide coupling reagents to suppress the racemization of the activated amino acid intermediate.  

Common coupling reagents include:

Carbodiimides (DCC, DIC, EDC)
Triaminophosphonium compounds (BOP, PyBOP, PyBrOP)
Tetramethylaminium/Tetramethyluronium compounds (HATU, HBTU, HCTU, etc.)

AAPPTec provides the highest purity coupling reagents at very competitive prices.

Showing 1–25 of 46 results

  • 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole  [26198-19-6]
    Catalog # Product Name Unit Price Qty
    CXZ096 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
    $45.00
  • 9-Fluorenyl-methanol  [24324-17-2]
    Catalog # Product Name Unit Price Qty
    CXZ006 9-Fluorenyl-methanol [24324-17-2]
    $140.00
  • AMC, 7-Amino-4-methylcoumarin [26093-31-2]
    Catalog # Product Name Unit Price Qty
    CXZ018 AMC, 7-Amino-4-methylcoumarin [26093-31-2]
    $50.00
  • Catalog # Product Name Unit Price Qty
    CXZ011 Boc Anhydride [24424-99-5]
    $175.00
  • Boc-ON  [58632-95-4]
    Catalog # Product Name Unit Price Qty
    CXZ016 Boc-ON [58632-95-4]
    $140.00
  • BOP  [56602-33-6]
    Catalog # Product Name Unit Price Qty
    CXZ001 BOP Reagent [56602-33-6]
    $45.00
  • BOP-Cl  [68641-49-6]
    Catalog # Product Name Unit Price Qty
    CXZ090 BOP-Cl [68641-49-6]
    $90.00
  • COMU   [1075198-30-9]
    Catalog # Product Name Unit Price Qty
    CXZ031 COMU [1075198-30-9]
    $55.00
  • Biotin  [58-85-5]
    Catalog # Product Name Unit Price Qty
    CXZ007 D-Biotin [58-85-5]
    $40.00
  • DEPBT  [165534-43-0]
    Catalog # Product Name Unit Price Qty
    CXZ060 DEPBT [165534-43-0]
    $120.00
  • DMAP  [1122-58-3]
    Catalog # Product Name Unit Price Qty
    CXZ019 DMAP [1122-58-3]
    $40.00
  • DMT-Cl  [40615-36-9]
    Catalog # Product Name Unit Price Qty
    CXZ008 DMT-Cl [40615-36-9]
    $60.00
  • DOTA-Tris(tBu) [137076-54-1]
    Catalog # Product Name Unit Price Qty
    CXZ038 DOTA-Tris(tBu) [137076-54-1]
    $150.00
  • DSC  [74124-79-1]
    Catalog # Product Name Unit Price Qty
    CXZ009 DSC [74124-79-1]
    $140.00
  • EDC HCl  [25952-53-8]
    Catalog # Product Name Unit Price Qty
    CXZ005 EDC HCl [25952-53-8]
    $45.00
  • Fmoc-6-HNA  [444794-69-8]
    Catalog # Product Name Unit Price Qty
    CXZ037 Fmoc-6-HNA [444794-69-8]
    $250.00
  • Fmoc-Cl  [28920-43-6]
    Catalog # Product Name Unit Price Qty
    CXZ014 Fmoc-Cl [28920-43-6]
    $50.00
  • Fmoc-NH2  [84418-43-9]
    Catalog # Product Name Unit Price Qty
    CXZ013 Fmoc-NH2 [84418-43-9]
    $125.00
  • Fmoc-OSu  [82911-69-1]
    Catalog # Product Name Unit Price Qty
    CXZ091 Fmoc-OSu [82911-69-1]
    $25.00
  • Placeholder
    Catalog # Product Name
    CXC001 Grubb’s Catalyst Please contact AAPPTec for a quotation.
  • HATU  [148893-10-1]
    Catalog # Product Name Unit Price Qty
    CXZ025 HATU [148893-10-1]
    $130.00
  • HBTU  [94790-37-1]
    Catalog # Product Name Unit Price Qty
    CXZ020 HBTU [94790-37-1]
    $50.00
  • HCTU  [330645-87-9]
    Catalog # Product Name Unit Price Qty
    CXZ030 HCTU [330645-87-9]
    $55.00
  • HOAt  [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    Catalog # Product Name Unit Price Qty
    CXZ012 HOAt [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    $40.00
  • HOBt  H2O   [123333-53-9]
    Catalog # Product Name Unit Price Qty
    CXZ010 HOBt H2O [123333-53-9]
    $150.00