Blog
Neuromedin B is essential for signaling sneezing
In a paper published in Cell, researchers have shown that the peptide neuromedin B (NMB) is essential for signaling sneezing. Mice deficient in NMB recptors and mice with NMB-sensitive neurons ablated in the sneeze-evoking region did not show the sneeze reflex....
Carbodiimides and Additives
Carbodiimides Carbodimides were some of the first coupling reagents used in solid phase peptide synthesis and are still used in many instances. Although carbodiimides might not couple as rapidly as newer coupling reagents, they still have advantages in certain...
SARS-CoV-2 Selected Papers November-December 2020
Vaccines against the SARS-CoV-2 virus are just becoming available. While this is good news for controlling the spread of the virus, there has not been as much success in developing therapeutic agents for treating patients infected with SARS-CoV-2. A significant...
Alkyne-Containing Amino Acids
Alkyne containing amino acids are useful building blocks for preparing modified peptides. Utilizing Sonogashira coupling or 1,3-cycloaddition with azides, they can form cyclized structures, conjugate with labels or biomolecules, and form structurally diverse amino...
Azide and Alkyne-Containing Amino Acids
Azide and alkyne containing amino acidsare useful building blocks for incorporating “click chemistry” into peptide synthesis. The copper(I) catalyzed 1,3-dipolar cycloaddition of azides with alkynes to form 1,4-substituted 1,2,3-triazoles is a convenient method for...
SARS CoV-2 Publications in September
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy,Rita E. Chen, Lauren Carter, Alexandra C. Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S....
Peptide Libraries for Epitope Detection of Pathogens and Vaccine Development
Hess and Loeffler (K. Hess, et al., J. Proteome Res., 2020, Published Sept. 5, 2020) have published a review of how peptide libraries and microarrays can be utilized to rapidly detect immunogenic epitopes of pathogens. These epitopes can be used to rapidly develop...
SARS-CoV-2 Publications in July
Covid-19 continues to be a major health problem. Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing. These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating...
SARS CoV-2 Publications in June
Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection. Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments. Listed below are a few...
Peptides and Covid-19
Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products: Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]...
Synthesizing Hydrophobic Peptides
Synthesizing hydrophobic peptides is often difficult. Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates. Measures to disrupt this hydrogen bonding often significantly improve the purity and...
Hmb and Dmb Protected Derivatives
Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding....
Fmoc-PEG Linkers and PEGylation Reagents
Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or...
High Performance Peptide Synthesizers
High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and...
Isoacyl Dipeptides
Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard peptide analogs...
Substance P recovers beta -amyloid-induced cognitive deficits in rats
Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels P Campolongo, P Ratano, MT Ciotti, F Florenzano, SL Nori, R Marolda, M Palmery, AM Rinaldi, C Zona, R Possenti, P Calissano, C...
Adrenomedullin and Alzheimer’s Disease
Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R MartÃnez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated...
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation Thoracic aorta was obtained from Wistar rats and VSMCs were isolated from aorta tissues and then cultured. In vitro cultured...
