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SARS CoV-2 Publications in June
Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection. Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments. Listed below are a few...
Peptides and Covid-19
Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products: Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]...
Synthesizing Hydrophobic Peptides
Synthesizing hydrophobic peptides is often difficult. Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates. Measures to disrupt this hydrogen bonding often significantly improve the purity and...
Hmb and Dmb Protected Derivatives
Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding....
PEG Linkers and PEGylation Reagents
Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or...
High Performance Peptide Synthesizers
High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and...
Isoacyl Dipeptides
Isoacyl Dipeptides Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard...
Substance P recovers beta -amyloid-induced cognitive deficits in rats
Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels P Campolongo, P Ratano, MT Ciotti, F Florenzano, SL Nori, R Marolda, M Palmery, AM Rinaldi, C Zona, R Possenti, P Calissano, C...
Adrenomedullin and Alzheimer’s Disease
Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R MartÃnez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated...
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation Thoracic aorta was obtained from Wistar rats and VSMCs were isolated from aorta tissues and then cultured. In vitro cultured...
Effects of Adrenomedullin on Doxorubicin-induced Cardiac Damage in Mice
Effects of Adrenomedullin on Doxorubicin-induced Cardiac Damage in Mice T Yoshizawa, S Takizawa, S Shimada, T Tokudome, T Shindo, K Matsumoto, Biol. Pharm. Bull., 2016, Advance publication Feb. 22. Doxorubicin (DOX) is one of the best known anticancer drugs, and is...
Endothelin 1 and Anxiety-Like Behaviors
Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM, Mol...
Design and Synthesis of Aphicidal Peptides
Eco-friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis and Aphicidal Activity of Novel Insect Kinin Analogs Chuan-liang Zhang, Yanyan Qv, Xiaoqing Wu, Dunlun Song, Yun Ling, and Xinling Yang, J. Agric. Food Chem., Just Accepted Manuscript...
Stereocontrolled Construction of (E)-2-Amino-2-butenamide
Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide Tomoya Yamashita, Takefumi Kuranaga, and Masayuki Inoue, Org. Lett., Article ASAP Publication Date (Web): April 13, 2015 Copyright © 2015...
Expanded Application of Native Chemical Ligation Using beta-Thio Phenylalanine and Desulfurization
Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry Lara R. Malins, Andrew M. Giltrap, Luke J. Dowman, and Richard J. Payne, Org. Lett., Article ASAP Publication Date (Web): April 10, 2015 Copyright © 2015 American...
Macrocyclic peptide with an unusual Lys-Trp crosslink
Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost, Nature Chemistry, 2015, 7, 431–437. Streptococcal bacteria use peptide signals as a...
A potent peptide inhibitor of α-synuclein aggregation.
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. Cheruvara H, Allen-Baume VL, Kad NM, Mason JM., J. Biol. Chem., 2015, First published on-line: January 23, 2015. DOI: 10.1074/jbc.M114.620484 Aggregation of...
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment Keith G. Davies, Brian Zimmerman, Ed Dudley,Russell P. Newton, John E. Hart, J. Exper. Biol., Published...
