Blog
PEG Linkers and PEGylation Reagents
Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or...
Pseudoproline Dipeptides
Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like...
High Performance Peptide Synthesizers
High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and...
Isoacyl Dipeptides
Isoacyl Dipeptides Isoacyl dipeptides are used to prepare desipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard...
Substance P recovers beta -amyloid-induced cognitive deficits in rats
Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels P Campolongo, P Ratano, MT Ciotti, F Florenzano, SL Nori, R Marolda, M Palmery, AMÂ Rinaldi, C Zona, R Possenti, P Calissano, C...
Adrenomedullin and Alzheimer’s Disease
Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R MartÃnez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally...
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation Thoracic aorta was obtained from Wistar rats and VSMCs were isolated from aorta tissues and then cultured. In vitro cultured...
Effects of Adrenomedullin on Doxorubicin-induced Cardiac Damage in Mice
Effects of Adrenomedullin on Doxorubicin-induced Cardiac Damage in Mice T Yoshizawa, S Takizawa, S Shimada, T Tokudome, T Shindo, K Matsumoto, Biol. Pharm. Bull., 2016, Advance publication Feb. 22. Doxorubicin (DOX) is one of the best known anticancer drugs, and is...
Endothelin 1 and Anxiety-Like Behaviors
Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu...
Design and Synthesis of Aphicidal Peptides
Eco-friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis and Aphicidal Activity of Novel Insect Kinin Analogs Chuan-liang Zhang, Yanyan Qv, Xiaoqing Wu, Dunlun Song, Yun Ling, and Xinling Yang, J. Agric. Food Chem., Just Accepted Manuscript...
Stereocontrolled Construction of (E)-2-Amino-2-butenamide
Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide Tomoya Yamashita, Takefumi Kuranaga, and Masayuki Inoue, Org. Lett., Article ASAP  Publication Date (Web): April 13, 2015  Copyright...
Expanded Application of Native Chemical Ligation Using beta-Thio Phenylalanine and Desulfurization
Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry Lara R. Malins, Andrew M. Giltrap, Luke J. Dowman, and Richard J. Payne, Org. Lett., Article ASAP  Publication Date (Web): April 10, 2015  Copyright © 2015...
Macrocyclic peptide with an unusual Lys-Trp crosslink
Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost, Nature Chemistry, 2015, 7, 431–437. Streptococcal bacteria use peptide signals as a...
A potent peptide inhibitor of α-synuclein aggregation.
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. Cheruvara H, Allen-Baume VL, Kad NM, Mason JM., J. Biol. Chem., 2015, First published on-line: January 23, 2015.  DOI: 10.1074/jbc.M114.620484...
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment Keith G. Davies, Brian Zimmerman, Ed Dudley,Russell P. Newton, John E. Hart, J. Exper. Biol., Published...
Anuran trypsin inhibitory peptides against Staphylococcal skin infection
Evaluation of in vivo efficacy of anuran trypsin inhibitory peptides against Staphylococcal skin infection and the impact of peptide cyclization U Malik,O. N. Silva, I. C. M. Fensterseifer, L. Y. Chan, R. J. Clark, O. L. Franco, N. L. Daly, D. J. Craik,...
CancerPPD: a database of anticancer peptides and proteins
CancerPPD: a database of anticancer peptides and proteins Atul Tyagi, Abhishek Tuknait, Priya Anand, Sudheer Gupta, Minakshi Sharma,Deepika Mathur, Anshika Joshi, Sandeep Singh, Ankur Gautam, Gajendra P.S. Raghava, Nucl. Acids Res. , 2015, 43, D837-D843....
Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic
Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic Alessandro Gori, Ching-I A. Wang, Peta J. Harvey, K. Johan Rosengren, Rebecca F. Bhola, Maria L. Gelmi, Renato Longhi, Macdonald J. Christie, Richard J....
