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Alkyne-Containing Amino Acids

Alkyne containing amino acids are useful building blocks for preparing modified peptides.  Utilizing Sonogashira coupling or 1,3-cycloaddition with azides, they can form cyclized structures, conjugate with labels or biomolecules, and form structurally diverse amino...

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Azide and Alkyne-Containing Amino Acids

Azide and alkyne containing amino acidsare useful building blocks for incorporating “click chemistry” into peptide synthesis.  The copper(I) catalyzed 1,3-dipolar cycloaddition of azides with alkynes to form 1,4-substituted 1,2,3-triazoles is a convenient method for...

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SARS CoV-2 Publications in September

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy,Rita E. Chen, Lauren Carter, Alexandra C. Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S....

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SARS-CoV-2 Publications in July

Covid-19 continues to be a major health problem.   Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing.  These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating...

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SARS CoV-2 Publications in June

Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection.  Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments.  Listed below are a few...

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Peptides and Covid-19

Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products:   Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]...

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Synthesizing Hydrophobic Peptides

Synthesizing hydrophobic peptides is often difficult.  Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates.  Measures to disrupt this hydrogen bonding often significantly improve the purity and...

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Hmb and Dmb Protected Derivatives

Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding....

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Fmoc-PEG Linkers and PEGylation Reagents

Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or...

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High Performance Peptide Synthesizers

High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and...

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Isoacyl Dipeptides

Isoacyl Dipeptides Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard...

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Adrenomedullin and Alzheimer’s Disease

Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R Martínez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated...

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Endothelin 1 and Anxiety-Like Behaviors

Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM, Mol...

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Design and Synthesis of Aphicidal Peptides

Eco-friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis and Aphicidal Activity of Novel Insect Kinin Analogs Chuan-liang Zhang, Yanyan Qv, Xiaoqing Wu, Dunlun Song, Yun Ling, and Xinling Yang, J. Agric. Food Chem., Just Accepted Manuscript...

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