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Coupling Reagents for Solid Phase Peptide Synthesis

Coupling reagents for peptide synthesis are used to form the amide bonds that link separate amino acids into peptides and proteins. They are also used to connect Boc amino acid or Fmoc amino acids to peptide synthesis resins, connect peptide synthesis linker molecules to base resins, and to form ester bonds in depsipeptides. Peptide coupling reagents react with protected amino acids to form activated amino acid intermediates which in turn react with the N-terminal amine of the peptide to form the elongated peptide. Formation of the activated amino acid intermediate can cause partial racemization of the amino acid which introduces impurities and reduces the yield of the desired peptide product. To minimize this problem, peptide coupling additives such as Oxyma are used with the coupling reagents to suppress the racemization of the activated amino acid intermediate.

Showing 1–25 of 28 results

  • 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole  [26198-19-6]
    Catalog # Product Name Unit Price Qty
    CXZ096 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
    $45.00
  • BOP  [56602-33-6]
    Catalog # Product Name Unit Price Qty
    CXZ001 BOP Reagent [56602-33-6]
    $45.00
  • BOP-Cl  [68641-49-6]
    Catalog # Product Name Unit Price Qty
    CXZ090 BOP-Cl [68641-49-6]
    $90.00
  • COMU   [1075198-30-9]
    Catalog # Product Name Unit Price Qty
    CXZ031 COMU [1075198-30-9]
    $55.00
  • DEPBT  [165534-43-0]
    Catalog # Product Name Unit Price Qty
    CXZ060 DEPBT [165534-43-0]
    $120.00
  • DSC  [74124-79-1]
    Catalog # Product Name Unit Price Qty
    CXZ009 DSC [74124-79-1]
    $140.00
  • EDC HCl  [25952-53-8]
    Catalog # Product Name Unit Price Qty
    CXZ005 EDC HCl [25952-53-8]
    $45.00
  • HATU  [148893-10-1]
    Catalog # Product Name Unit Price Qty
    CXZ025 HATU [148893-10-1]
    $130.00
  • HBTU  [94790-37-1]
    Catalog # Product Name Unit Price Qty
    CXZ020 HBTU [94790-37-1]
    $50.00
  • HCTU  [330645-87-9]
    Catalog # Product Name Unit Price Qty
    CXZ030 HCTU [330645-87-9]
    $55.00
  • Catalog # Product Name Unit Price Qty
    CXZ023 HDMC [1082951-62-9]
    $125.00
  • HOAt  [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    Catalog # Product Name Unit Price Qty
    CXZ012 HOAt [39968-33-7] 1-Hydroxy-7-azabenzotriazole
    $40.00
  • HOBt  H2O   [123333-53-9]
    Catalog # Product Name Unit Price Qty
    CXZ010 HOBt H2O [123333-53-9]
    $150.00
  • HOOBT  [28230-32-2]
    Catalog # Product Name Unit Price Qty
    CXZ015 HOOBT [28230-32-2]; HODHBt
    $70.00
  • HOSu  [6066-82-6]
    Catalog # Product Name Unit Price Qty
    CXZ022 HOSu [6066-82-6]
    $90.00
  • Ethyl (hydroxyimino)cyanoacetate  [3849-21-6] (OxymaPure)
    Catalog # Product Name Unit Price Qty
    CXZ021 OxymaPure [Ethyl (hydroxyimino)cyanoacetate] [3849-21-6]
    $45.00
  • PyAOP  [156311-83-0]
    Catalog # Product Name Unit Price Qty
    CXZ070 PyAOP [156311-83-0]
    $55.00
  • PyBOP  [128625-52-5]
    Catalog # Product Name Unit Price Qty
    CXZ050 PyBOP [128625-52-5]
    $55.00
  • PyBroP  [132705-51-2]
    Catalog # Product Name Unit Price Qty
    CXZ055 PyBroP [132705-51-2]
    $70.00
  • Catalog # Product Name Unit Price Qty
    CXZ075 PyOxim [153433-21-7]
    $45.00
  • TATU  [873798-09-5]
    Catalog # Product Name Unit Price Qty
    CXZ045 TATU [873798-09-5]
    $45.00
  • TBTU  [125700-67-6]
    Catalog # Product Name Unit Price Qty
    CXZ040 TBTU [125700-67-6]
    $40.00
  • TCFH  [207915-99-9]
    Catalog # Product Name Unit Price Qty
    CXZ042 TCFH [207915-99-9]
    $75.00
  • TDBTU  [125700-69-8]
    Catalog # Product Name Unit Price Qty
    CXZ065 TDBTU [125700-69-8]
    $165.00
  • TNTU  [125700-73-4]
    Catalog # Product Name Unit Price Qty
    CXZ043 TNTU [125700-73-4]
    $95.00