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Home » Peptide Synthesis Reagents » Coupling Reagents for Solid Phase Peptide Synthesis

Coupling Reagents for Solid Phase Peptide Synthesis

Coupling reagents for peptide synthesis are used to form the amide bonds that link separate amino acids into peptides and proteins. They are also used to connect Boc amino acid or Fmoc amino acids to peptide synthesis resins, connect peptide synthesis linker molecules to base resins, and to form ester bonds in depsipeptides. Peptide coupling reagents react with protected amino acids to form activated amino acid intermediates which in turn react with the N-terminal amine of the peptide to form the elongated peptide. Formation of the activated amino acid intermediate can cause partial racemization of the amino acid which introduces impurities and reduces the yield of the desired peptide product. To minimize this problem, peptide coupling additives such as Oxyma are used with the coupling reagents to suppress the racemization of the activated amino acid intermediate.

Showing 1–25 of 27 results

  • 6-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
    Catalog #Product NameUnitPriceQty
    CXZ0966-Cl-HOBt, 1-Hydroxy-6-chloro-benzotriazole [26198-19-6]
    $108.00
  • BOP [56602-33-6]
    Catalog #Product NameUnitPriceQty
    CXZ001BOP Reagent [56602-33-6]
    $78.00
  • BOP-Cl [68641-49-6]
    Catalog #Product NameUnitPriceQty
    CXZ090BOP-Cl [68641-49-6]
    $108.00
  • COMU [1075198-30-9]
    Catalog #Product NameUnitPriceQty
    CXZ031COMU [1075198-30-9]
    $66.00
  • DEPBT [165534-43-0]
    Catalog #Product NameUnitPriceQty
    CXZ060DEPBT [165534-43-0]
    $144.00
  • DSC [74124-79-1]
    Catalog #Product NameUnitPriceQty
    CXZ009DSC [74124-79-1]
    $168.00
  • EDC HCl [25952-53-8]
    Catalog #Product NameUnitPriceQty
    CXZ005EDC HCl [25952-53-8]
    $84.00
  • HATU [148893-10-1]
    Catalog #Product NameUnitPriceQty
    CXZ025HATU [148893-10-1]
    $156.00
  • HBTU [94790-37-1]
    Catalog #Product NameUnitPriceQty
    CXZ020HBTU [94790-37-1]
    $81.60
  • HCTU [330645-87-9]
    Catalog #Product NameUnitPriceQty
    CXZ030HCTU [330645-87-9]
    $66.00
  • HDMC [1082951-62-9]
    Catalog #Product NameUnitPriceQty
    CXZ023HDMC [1082951-62-9]
    $150.00
  • HOBt H2O [123333-53-9]
    Catalog #Product NameUnitPriceQty
    CXZ010HOBt H2O [123333-53-9]
    From: $180.00
  • HOPO [13161-30-3]
    Catalog #Product Name
    CXZ032HOPO [13161-30-3]Please contact AAPPTec for a quotation.
  • HOSu [6066-82-6]
    Catalog #Product NameUnitPriceQty
    CXZ022HOSu [6066-82-6]
    $132.00
  • Ethyl (hydroxyimino)cyanoacetate [3849-21-6] (OxymaPure)
    Catalog #Product NameUnitPriceQty
    CXZ021OxymaPure [Ethyl (hydroxyimino)cyanoacetate] [3849-21-6]
    $54.00
  • PyAOP [156311-83-0]
    Catalog #Product NameUnitPriceQty
    CXZ070PyAOP [156311-83-0]
    $66.00
  • PyBOP [128625-52-5]
    Catalog #Product NameUnitPriceQty
    CXZ050PyBOP [128625-52-5]
    $66.00
  • PyBroP [132705-51-2]
    Catalog #Product NameUnitPriceQty
    CXZ055PyBroP [132705-51-2]
    $84.00
  • PyOxim [153433-21-7]
    Catalog #Product NameUnitPriceQty
    CXZ075PyOxim [153433-21-7]
    From: $54.00
  • TATU [873798-09-5]
    Catalog #Product NameUnitPriceQty
    CXZ045TATU [873798-09-5]
    $54.00
  • TBTU [125700-67-6]
    Catalog #Product NameUnitPriceQty
    CXZ040TBTU [125700-67-6]
    $48.00
  • TCFH [207915-99-9]
    Catalog #Product NameUnitPriceQty
    CXZ042TCFH [207915-99-9]
    $90.00
  • TDBTU [125700-69-8]
    Catalog #Product NameUnitPriceQty
    CXZ065TDBTU [125700-69-8]
    $198.00
  • TNTU [125700-73-4]
    Catalog #Product NameUnitPriceQty
    CXZ043TNTU [125700-73-4]
    $114.00
  • TOTU [136849-72-4]
    Catalog #Product NameUnitPriceQty
    CXZ044TOTU [136849-72-4]
    $96.00