PEG derivatives for peptide synthesis are used to improve the solubility of hydrophobic peptides, enhance the bio-availability of bio-active peptides, and to shield peptides from triggering an immune response. Polyethyleneglycol (PEG) derivatives have an amphiphilic nature. They can be utilized to improve the solubility of peptides in aqueous or organic solvents. Bifunctional PEGs, such as PEG amino acids, are useful linkers and spacers for conjugating peptides to proteins, fluorescent labels, or other tags. PEGs are biocompatible, which means they are useful linkers for preparing drug candidates or labeled peptides in biological studies. These PEG derivatives can be utilized in solid phase peptide synthesizers or may be used in solution phase synthesis.
AAPPTec offers PEG amino acid derivatives in a variety of lengths. Chemists can choose a liker with sufficient length to prevent steric interference between the tag and the labeled biomolecule. If longer spacers are desired, PEG amino acids can be linked to produce a linker of the appropriate length.
AAPPTec PEG derivatives are monodisperse. Unlike the common polydisperse PEGs, the monodisperse PEG compounds are single chemical entities. Thus peptides and other products prepared from them are homogeneous products and can be purified and characterized using standard techniques.