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N-Methyl Amino Acids

Replacing standard amino acid residues with N-methyl amino acids can improve the pharmacokinetic properties of bioactive peptides and produce viable drug candidates. Many peptides are readily metabolized by proteolytic enzymes resulting in a short half-life in vivo. Introducing N-methyl amino acids generally increases the enzymatic stability of peptides, thus increasing their in vivo half-life. Most peptides either are hydrolyzed by digestive enzymes or are poorly absorbed through the intestine, resulting in poor oral availability. Substituting in N-methyl amino acids can increase peptidase stability and enhance intestinal permeability. Recent reports show that peptides rich in N-methyl phenylalanine passively diffuse across the blood-brain barrier and can be used as blood-brain barrier shuttles.

Including N-methyl amino acids in peptides can enhance activity and selectivity or convert an agonist to an antagonist. These changes are usually attributed to reduced backbone flexibility resulting from N-methyl groups. The N-methyl groups also inhibit hydrogen bonding, resulting in improved water solubility in hydrophobic Aβ peptides.

AAPPTec has a broad selection of Boc-N-Me-amino acids, Fmoc-N-Me-amino acids and unprotected N-methyl amino acids. All AAPPTec N-Methyl amino acid products are available in bulk quantities. Contact us at info@aapptec.com for a quotation for larger quantities.

Showing 1–25 of 52 results

  • Boc-D-MeAla-OH  [19914-38-6]
    Catalog # Product Name Unit Price Qty
    MBA201 Boc-D-MeAla-OH [19914-38-6]
    $45.00
  • Boc-D-MePhe-OH DCHA  [102185-45-5]
    Catalog # Product Name Unit Price Qty
    MBF201 Boc-D-MePhe-OH DCHA [102185-45-5]
    $165.00
  • Boc-D-MePhg-OH
    Catalog # Product Name Unit Price Qty
    MBU201 Boc-D-MePhg-OH
    $120.00
  • Boc-MeAla-OH  [16948-16-6]
    Catalog # Product Name Unit Price Qty
    MBA101 Boc-MeAla-OH [16948-16-6]
    $55.00
  • Boc-MePhe-OH  [37553-65-4]
    Catalog # Product Name Unit Price Qty
    MBF102 Boc-MePhe-OH [37553-65-4]
    $95.00
  • Boc-MePhe-OH DCHA  [40163-88-0]
    Catalog # Product Name Unit Price Qty
    MBF101 Boc-MePhe-OH DCHA [40163-88-0]
    $160.00
  • Boc-MePhg-OH   [30925-11-2]
    Catalog # Product Name Unit Price Qty
    MBU101 Boc-MePhg-OH [30925-11-2]
    $50.00
  • Boc-MeTyr-OH DCHA  [95105-25-2]
    Catalog # Product Name Unit Price Qty
    MBY101 Boc-MeTyr-OH DCHA [95105-25-2]
    $60.00
  • Boc-MeTyr(Bzl)-OH  [64263-81-6]
    Catalog # Product Name Unit Price Qty
    MBY110 Boc-MeTyr(Bzl)-OH [64263-81-6]
    $45.00
  • Boc-MeVal-OH  [45170-31-8]
    Catalog # Product Name Unit Price Qty
    MBV101 Boc-MeVal-OH [45170-31-8]
    $55.00
  • Boc-Sar-OH  [13734-36-6]
    Catalog # Product Name Unit Price Qty
    UBG051 Boc-Sar-OH [13734-36-6]
    $115.00
  • Fmoc-Arg(Me)2-OH HCl sym.
    Catalog # Product Name Unit Price Qty
    AFR125 Fmoc-Arg(Me)2-OH HCl sym.
    $245.00
  • Fmoc-Arg(Me)2-OH unsym.  [268564-10-9]
    Catalog # Product Name Unit Price Qty
    AFR127 Fmoc-Arg(Me)2-OH unsym. [268564-10-9]
    $200.00
  • Fmoc-D-MeLeu-OH  [103476-63-3]
    Catalog # Product Name Unit Price Qty
    MFL201 Fmoc-D-MeLeu-OH [103476-63-3]
    $40.00
  • Fmoc-D-MePhe-OH  [138775-05-0]
    Catalog # Product Name Unit Price Qty
    MFF201 Fmoc-D-MePhe-OH [138775-05-0]
    $85.00
  • Fmoc-D-MeVal-OH  [103478-58-6]
    Catalog # Product Name Unit Price Qty
    MFV201 Fmoc-D-MeVal-OH [103478-58-6]
    $40.00
  • Fmoc-Lys(Boc,Me)-OH  [951695-85-5]
    Catalog # Product Name Unit Price Qty
    AFK150 Fmoc-Lys(Boc,Me)-OH [951695-85-5]
    $400.00
  • Fmoc-Lys(Me)2-OH HCl  [252049-10-8]
    Catalog # Product Name Unit Price Qty
    AFK151 Fmoc-Lys(Me)2-OH HCl [252049-10-8]
    $110.00
  • Fmoc-Lys(Me3)-OH+Cl-  [201004-29-7]
    Catalog # Product Name Unit Price Qty
    AFK152 Fmoc-Lys(Me3)-OH+Cl- [201004-29-7]
    $175.00
  • Fmoc-MeAla-OH  [84000-07-7]
    Catalog # Product Name Unit Price Qty
    MFA101 Fmoc-MeAla-OH [84000-07-7]
    $45.00
  • Fmoc-MeArg(Pbf)-OH  [913733-27-4]
    Catalog # Product Name Unit Price Qty
    MFR105 Fmoc-MeArg(Pbf)-OH [913733-27-4]
    $400.00
  • Fmoc-MeAsn(Trt)-OH  [941296-80-6]
    Catalog # Product Name Unit Price Qty
    MFN105 Fmoc-MeAsn(Trt)-OH [941296-80-6]
    $300.00
  • Fmoc-MeAsp(OtBu)-OH  [152548-66-8]
    Catalog # Product Name Unit Price Qty
    MFD105 Fmoc-MeAsp(OtBu)-OH [152548-66-8]
    $140.00
  • Fmoc-MeCys(Trt)-OH  [944797-51-7]
    Catalog # Product Name Unit Price Qty
    MFC105 Fmoc-MeCys(Trt)-OH [944797-51-7]
    $400.00
  • Fmoc-MeGlu(OtBu)-OH  [200616-40-6]
    Catalog # Product Name Unit Price Qty
    MFE105 Fmoc-MeGlu(OtBu)-OH [200616-40-6]
    $185.00