Tuftsin comprises residues 289-292 of the Fc domain in the heavy chain of immunoglobulin G. Tuftsin is an immunostimulant that induces bactericidal and tumoricidal activities by promoting phagocytosis, antigen presentation, and cell migration. It also inhibits vascular endothelial growth factor (VEGF) by binding neurophilin-1 (NP-1). This peptide has been found to reduce EAE symptoms in mice. Kraus-Berthier, L; et al., Biochem Pharmacol., 41, 1411, (1991); von Wronski, M; et al., J. Biol. Chem., 281, 5702, (2006); Bhasin, M; et al., BMC Immunol., 8, 10, (2007).
M.W.: 500.6
