This peptide exhibits proapoptotic activity and triggers caspase-independent release of holocytochrome c. BH3 peptide provides cooperative functions that promote cell death through a mechanism dependent on the presence of either Bax or Bak. Bax is a proapoptotic Bcl-2 family member. c-Myc-induced apoptosis can be restored in bax-deficient cells by ectopic expression of Bax. Juin, P. et al. Mol. Cell Biol. 22, 6158 (2002); Chatzaki, E. et al. Molecular Human Reproduction 9, 91 (2003).
This peptide exhibits proapoptotic activity and triggers caspase-independent release of holocytochrome c. BH3 peptide provides cooperative functions that promote cell death through a mechanism dependent on the presence of either Bax or Bak. Bax is a proapoptotic Bcl-2 family member. c-Myc-induced apoptosis can be restored in bax-deficient cells by ectopic expression of Bax. Juin, P. et al., Mol. Cell Biol., 22, 6158 (2002); Chatzaki, E. et al. Molecular Human Reproduction, 9, 91 (2003).
