This Epidermal Growth Factor-derived peptide is known as a laminin antagonist. It blocks the stimulatory effects of laminin in cell motility and chick angiogenesis. This peptide binds to a breast cancer- and endothelial cell-associated receptor, which is specific for residues 925 to 933 of the laminin B1 chain. This peptide has an antimetastatic potential. Nelson, J.; et al., J. Biol. Chem., 271, 26179, (1996).
Ac-[Cys(Acm)33,42]-EGF (33-42) amide, mouse
Sequence: Ac-Cys(Acm)-Val-Ile-Gly-Tyr-Ser-Gly-Asp-Arg-Cys(Acm)-NH2
Synonym: Ac-
Molecular Weight: 1255.45
Molecular Formula: C51H82N16O17S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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