N-Boc-O-(2-bromo-Z)-L-tyrosine
Other Names: Boc-L-Tyr(2-Br-Z)-OH
Catalog #: ABY115
CAS #: 47689-67-8
Formula: C22H24BrNO7
M.W.: 494.3
Boc-Tyr(2-Br-Z)-OH is a tyrosine derivative utilized in Boc SPPS. The 2-Br-Z group is stable to the repeated acidic conditions used to remove Boc groups in peptide synthesis, so Boc-Tyr(2-Br-Z)-OH is often used when a tyrosine residue occurs early in the sequence of large peptides. The 2-Br-Z group is removed with HF, TFMSA, or TMSOTf when the peptide is cleaved from the resin. It can also be removed with piperidine in DMF.
