SH2 domains bind to the conserved sequence of Glu-Glu-Ile following a phosphorylated Tyr. The native peptide may therefore be an extremely effective SH2 domain binding probe. It binds to Src SH2 domain with high affinity. Eck, MJ; et al., Nature, 362, 87 (1993); Nam, N; et al., Bioorg. Med. Chem., 12, 779 (2004).
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