This peptide is a selective ET receptor subtype B agonist. In experiments on renal vasoconstrictor actions, sarafotoxin 6c appears to be potent at the renal resistance vasculature and is powerfully modulated by NO. It plays a role in cytosolic Ca2+ concentration ([Ca2+]i) balance. Mills, R; et al., J. Biol. Chem., 269, 23413 (1994); Watanabe, C; et al., Br. J. Pharmacol., 108, 30 (1993); Marshall, JL; Edward JJ., Br. J. Pharmacol., 128, 809 (1999).
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