This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells. Ellerby, H; et al., Nature Med., 5, 1032, (1999); Gerlag, M; et al., Arthritis Res., 3, 357, (2001); Su, Z; et al., Bioconjug. Chem., 13, 561, (2002); Curnis, F; et al., Cancer Res., 64, 565, (2004).
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