Renoguanylin is an osmoregulatory guanylin elucidated from cDNA libraries from eel. It significantly reduces bicarbonate reabsorption by rat renal tubules. Yuge, S; et al., J. Biol. Chem., 278, 22726, (2003); Lessa, LMA; et al., Reg. Pept., 157, 37, (2009).
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