Bid BH3-r8 contains 8 Arg residues on the N-terminus to facilitate cell internalization. R8BIDH3 has been shown to induce apoptosis of Jurkat leukemia cells in vitro. Letai, A., J. Clin. Invest., 115, 2648 (2005). Goldsmith, K. et al., Proc. Amer. Assoc. Cancer Res., 45, 1829 (2004). Goldsmith, K. et al., Oncogene, 25, 4525 (2006).
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