BID is a pro-apoptotic member of the “BH3-only” (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid acts as a death-inducing ligand that travels to the mitochondrial membrane from the cytosol to inactivate Bcl-2 or to activate Bax. Oh, K. J. et al, J. Biol. Chem., 280, 753 (2005); Oh, K. J. et al., J. Biol. Chem., 281, 36999 (2006); Manero, F. et al., Cancer Res., 66, 2757 (2006); Zhai, D. et al., J. Biol. Chem., 280, 15815 (2005); Walensky, LD. et al., Mol. Cell., 24, 199 (2006); Onuki, R. et al. Proc. Natl. Acad. Sci. USA, 99, 14716 (2002); Wang, K., Gen. Develop., 10, 2859 (1996).
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