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COMU is a high efficiency coupling reagent.The superior reactivity of COMU can be observed by comparing the yields of difficult Aib-Aib coupling performed with the different coupling reagents.COMU can be utilized with the same protocols as HBTU and HATU.In applications where racemization is a significant concern, only one equivalent of base can be used because the morpholino group of COMU acts as an internal base