TBTU [125700-67-6]
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
Catalog #: CXZ040
CAS #: 125700-67-6
Formula: C11H16BF4N5O
M.W.: 321.08
TBTU has the same reactivity as HBTU. It has been utilized to couple Fmoc-amino acids to Hmb-protected amino acids (W Zeng, et al., J. Pept. Res., 1997, 49, 273-9). Recently, TBTU was used to prepare peptaibols by a solution phase fragment condesation protocol (P Blaser, et al., Chem. Biodivers., 2013, 10, 920-41; N Pradeille, et al., Chem. Biodivers., 2012, 9, 2528-58).
TBTU Physical Properties
Assay: 99+%
White to off-white powder
200-205 °C (dec)
Solubility: 1 mmol in 2 mL DMF
Storage temp: 2-8 °C
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