TBTU [125700-67-6]

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

TBTU has the same reactivity as HBTU. It has been utilized to couple Fmoc-amino acids to Hmb-protected amino acids (W Zeng, et al., J. Pept. Res., 1997, 49, 273-9).  Recently, TBTU was used to prepare peptaibols by a solution phase fragment condesation protocol (P Blaser, et al., Chem. Biodivers., 2013, 10, 920-41; N Pradeille, et al., Chem. Biodivers., 2012, 9, 2528-58).

TBTU Physical Properties

Assay: 99+%

White to off-white powder

200-205 °C (dec)

Solubility: 1 mmol in 2 mL DMF

Storage temp: 2-8 °C 

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