Urocotin II (human) binds selectively to the type 2 CRF receptor (CRF-R2), with no appreciable activity on CRF-R1. Lewis, K; et al., Proc. Natl. Acad. Sci. USA, 98, 7570 (2001); Reyes, T.M.; et al., Proc. Natl. Acad. Sci. USA, 98, 2843 (2001). UrocortinII has pro-inflammatory effects in human intestinal cells via the CRHR2α receptor and may play an important role in the pathophysiology of colitis in humans. Moss, AC; et al., Gut, 56, 1210, (2007).
MW: 4449.31