Urocortin is a mammalian neuropeptide related to fish urotensin and to corticotropin-releasing factor. It binds with high affinity to CRF receptor types 1, 2α, and 2β, stimulates cAMP accumulation from cells transfected with these receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells. Vaughan, J.; et al., Nature, 378, 287, (1995); Donaldson, C.J.; et al., Endocrinology, 137, 2167, (1996).
MW: 4696.3
