Other Names: PAR-1-selective peptide
Protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation. Syeda, F; et al., J. Biol. Chem., 281, 11792, (2006); Jenkins, R; et al., J. Clin. Invest., 116, 1606, (2006).