Prion Peptide (106-126), human mimics the physiochemical properties of Scrapie prion protein (PrPSc). It adopts predominantly a beta-sheet structure which forms amyloid fibrillar aggregates. This peptide displays neurotoxicity and induces microglial activation. Forloni, G; et al., Nature, 362, 543 (1993); Ettaiche, M; et al., J. Biol. Chem., 275, 36487 (2000); White, AR; et al., Neurobio. Dis., 8, 299, (2001); O’Donovan, CN, et al., J. Biol. Chem., 276, 43516 (2001); Fabrizi, C; et al., J. Biol. Chem., 276, 25692 (2001); Della-Bianca, V; et al., J. Biol. Chem., 276, 38929 (2001); Gu, Y; et al., J. Biol. Chem., 277, 2275 (2002).
M.W.: 1912.28
