Leuprorelin is a highly active LHRH agonist that stimulates release of luteinizing hormone by the pituitary resulting in an increase of testicular androgen production. Coy, DH; Schally, AV., Ann. Clin. Res., 10, 139, (9178); Dutta, AS., Drugs Future, 13, 43, (1988); Mizutani, T; et al., Int. J. Fertil. Menopaus. Stud., 40, 106, (1995); Imai, A; et al., J. Oncol., 20, 987, (2002); Meyer, JD; et al., J. Pept. Res., 60, 159, (2002); Castellon, E; et al., Cancer Invest., 24, 261, (2006); Levine, D; et al., J. Reprod. Med., 52, 581, (2007).
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