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[Glu2]-Thyrotropin-Releasing Hormone [85541-78-2]

Catalog Number: P000728
Sequence: Pyr-Glu-Pro-NH2
CAS Number: [85541-78-2]
Molecular Weight: 354.38
Molecular Formula: C15H22N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
Catalog #Product NameUnitPriceQty
P000728[Glu2]-Thyrotropin-Releasing Hormone [85541-78-2]

Other Names: [Glu2]-TRH

While [Glu2]-TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time.  [Glu2]-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]-TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain. Nguyen, V.; et al., Neurosci. Lett., 415, 64, (2007); Nguyen, V.; et al., Brain Res. Bull., 82, 83, (2010).

M.W.: 354.38