Other Names: [Glu2]-TRH
While [Glu2]-TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. [Glu2]-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]-TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain. Nguyen, V.; et al., Neurosci. Lett., 415, 64, (2007); Nguyen, V.; et al., Brain Res. Bull., 82, 83, (2010).