Fmoc-Lys(ivDde)-OH [204777-78-6]

N-alpha-Fmoc-N-epsilon-ivDde-L-lysine

Molecular Weight: 574.8

The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups. Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain (Chhabra, S.R .; et al. Tetraheron Lett., 1998, 39, 1603-9). As examples of its use, Fmoc-Lys(ivDde)-OH was used to prepare a chlorothalonil peptide conjugate with the pesticide conjugated to the peptide through the Lys sidechain (Hrenn, H.; et al. Tetrahedron Lett., 2003, 44, 1911-3). Fmoc-Lys(ivDde)-OH was also used to palmitoytlate selected Lys residues while leaving other Lys residues unmodified for subsequent labeling (Olschewski, D.; et al. Chem. Biol., 2007, 14, 994-1006).

Removal of ivDde Groups