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Catalog Number: P001271
Sequence: Lys-Lys-Ala-Leu-His-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu
Synonym: Autocamtide-3
Molecular Weight: 1508.75
Molecular Formula: C65H113N21O20
* Refer to Certificate of Analysis for lot specific data (including water content).
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Autocamtide-3 is a synthetic substrate specific for Ca2+/calmodulin-dependent protein kinase II. The sequence is based on the pseudosubstrate core located within the autoinhibitory domain of the enzyme. Autophosphorylation of Thr286 within the autoinhibitory domain traps bound calmodulin by greatly reducing its dissociation rate, thus prolonging the active state.  Fluck, M. et al., J. Appl. Physiol., 88, 352, (2000); Yang, E.; Schulman, H., J. Biol. Chem., 274, 26199, (1999).

MW: 1508.75