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Home » Shop » Catalog Peptides » Substance P » [Arg6, D-Trp7,9, N-MePhe8]-Substance P (6-11) [115150-59-9]

[Arg6, D-Trp7,9, N-MePhe8]-Substance P (6-11) [115150-59-9]

Catalog Number: P001234
Sequence: Arg-D-Trp-N-Me-Phe-D-Trp-Leu-Met-NH2
CAS Number: [115150-59-9]
Molecular Weight: 951.2
Molecular Formula: C49H62O6N12S
* Refer to Certificate of Analysis for lot specific data (including water content).
Catalog #Product NameUnitPriceQty
P001234[Arg6, D-Trp7,9, N-MePhe8]-Substance P (6-11) [115150-59-9]

Other Names: Antagonist G

[Arg6, D-Trp7,9, N-MePhe8]-Substance P (6-11) is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.  Woll, PJ; Rozengurt, E., Cancer Res., 50, 3968, (1990); Langdon, S; et al., Cancer Res., 52, 4554, (1992); MacKinnon, AC; et al., Br. J. Cancer, 83, 941, (2000).

MW: 951.2