Other Names: Antagonist G
[Arg6, D-Trp7,9, N-MePhe8]-Substance P (6-11) is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo. Woll, PJ; Rozengurt, E., Cancer Res., 50, 3968, (1990); Langdon, S; et al., Cancer Res., 52, 4554, (1992); MacKinnon, AC; et al., Br. J. Cancer, 83, 941, (2000).