2-Chlorotrityl Chloride Resin

Other Names: 2-Cl-Trt chloride resin

2-Chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave Boc/tBu based protecting groups in place.  Thus it is used to prepare protected peptide fragments.  Amino acids can be attached to 2-Cl-Trt chloride resin with very little or no racemization.  The steric bulk of 2-chlorotrityl chloride resin inhibits diketopiperazine formation, which can be a major side reaction in the synthesis of peptides with C-terminal proline.

100-200 mesh, 1% DVB  Typical substitution levels range from 0.8 mmol/g to 1.5 mmol/g.  Other substitutions, mesh sizes or crosslinking are available by request.

Loading and Cleavage Procedures