Other Names: 2-Cl-Trt chloride resin
2-Chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave Boc/tBu based protecting groups in place. Thus it is used to prepare protected peptide fragments. Amino acids can be attached to 2-Cl-Trt chloride resin with very little or no racemization. The steric bulk of 2-chlorotrityl chloride resin inhibits diketopiperazine formation, which can be a major side reaction in the synthesis of peptides with C-terminal proline.
100-200 mesh, 1% DVB Typical substitution levels range from 0.8 mmol/g to 1.5 mmol/g. Other substitutions, mesh sizes or crosslinking are available by request.