MAP Resins

Multiple Antigen Peptide (MAP) resins provide a branching core matrix for preparing synthetic peptide antigens. MAP peptides produced on these resins are utilized as synthetic vaccines and produce anti-peptide antibodies. By incorporating a cysteine residue into the core matrix, MAP peptides may be conjugated with additional antigens, tags, linkers or biomolecules.

Multiple Antigen Peptide System

Multiple Antigen Peptides (MAPs) were developed by J.P. Tam to produce high-titer anti-peptide antibodies and synthetic peptide vaccines. The MAP system utilizes radially branched lysine residues to form a backbone to which multiple peptide chains are attached. Typically, the antigen sequences are synthesized on a lysine core attached to a solid phase synthesis resin. Depending on the lysine core, the MAP will contain four (4-branch) or eight (8-branch) copies of the peptide epitope. Generally, the lysine core accounts for less than 10% of the total molecular weight of the MAP. Thus the dense packing of multiple copies of the epitope and its high molar ratio produce a strong immunological response. Therefore the multiple antigen peptide system does not need a carrier protein for conjugation.