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Unusual Amino Acids

Unusual amino acids occur most frequently in microbial peptides and proteins and are formed post-translationally.  The unusual amino acids often contribute to the special bioactivity of these peptides and proteins.  In drug development, unusual amino acids are used to enhance the pharmaceutical properties of a peptide drug lead.

Unusual amino acids incorporated into a peptide can:

  • Improve receptor binding
  • Improve selectivity
  • Modify activity (agonists and antagonists)
  • Increase in vivo half-life
  • Enhance transport across cell membranes

AAPPTec has a large selection of high quality, optically pure unusual amino acids including:

If you require a special amino acid that is not in the AAPPTec catalog, please Request a Quotation.  AAPPTec can provide most unusual amino acids at a reasonable cost.

All AAPPTec unusual amino acid products are available in gram to kilogram quantities.  Please email  AAPPTec at for a quotation on large quantities or use the On-Line Quote Request.

AAPPTec has recently added over 180 new unusual amino acid products.  For a list of these new products, click HERE.