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Boc-Amino Acids

Boc-amino acids were used by Bruce Merrifield in developing solid phase peptide synthesis and they remain popular today. Boc-amino acids are easily dissolved in all of the solvents commonly utilized in solid phase peptide synthesis, including dichloromethane (DCM), N,N-dimethylformamide (DMF), and N-methyl-2-pyrrolidone (NMP). The Boc group is removed with trifluoroacetic acid (TFA), leaving the N-terminus of the peptide protonated. DCM is commonly used with Boc-amino acids, because DMF and NMP are protonated by TFA which retards the Boc-deprotection.

AAPPTec offers high purity

Boc-Amino Acids are available in bulk quantities.  Please send an e-mail to for a quotation.

Boc-Cys(MeBzl)Boc-Cys(MeBzl)-OH shown