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HOBt hydrate [123333-53-9]

1-Hydroxybenzotriazole hydrate

Other Names: HOBt H2O

Catalog #: CXZ010

CAS #: 123333-53-9

Formula: C6H7N3O2

M.W.: 153.1

HOBt hydrate

 

 

 

 

HOBt hydrate is utilized in solid phase peptide synthesis as an additive during amino acid activation and coupling to suppress racemization.  It is reported that adding a small amount of HOBt to the Fmoc cleavage solution can suppress aspartimide formation.  (T. Michels, et al., Org. Lett., 2012, 14, 5218-21)  Anhydrous HOBt poses a risk of explosion, but HOBt hydrate is desensitized.

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