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Fmoc-Lys(Boc)-OH [71989-26-9]

N-alpha-Fmoc-N-epsilon-Boc-L-lysine

Other Names: Fmoc-L-Lys(Boc)-OH; Nα-Fmoc-Nε-Boc-L-lysine

Catalog # AFK105

CAS 71989-26-9

Formula C26H32N2O6

M.W. 468.5

Fmoc-Lys(Boc)-OH







Fmoc-Lys(Boc)-OH is the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. Methylation or acetylation of lysine side chains in histones play important roles in DNA regulation. AAPPTec offers side chain methylated or acetylated lysine derivatives suitably protected for for solid phase peptide synthesis. Lysine residues also are convenient sites for attaching tags or dye labels. AAPPTec provides Fmoc-Lys derivatives with side chain protecting groups that can be selectively removed. The 2-Cl-Z group of Fmoc-Lys(2-Cl-Z)-OH can be removed by hydrogenolysis following peptide cleavage from the resin (Technical Bulletin 1169). Fmoc-Lys(Dde)-OH and Fmoc-Lys(ivDde)-OH can be sidechain deprotected with hydrazine or hydroxylamine (Technical Bulletin 1182). Fmoc-Lys(Mtt)-OH can be deprotected with mild acid (Technical Bulletin 1181) and Fmoc-Lys(Trt)-OH can be deprotected with moderate acid. Fmoc-Lys(Aloc)-OH can be deprotected selectively under mild conditions with palladium catalyst (Technical Bulletin 1144).

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MSDS