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Fmoc-His(Trt)-OH [109425-51-6]

N-alpha-Fmoc-N-im-trityl-L-histidine

Other Names: Fmoc-L-His(Trt)-OH; Nα-Fmoc-Nτ-triphenylmethyl-L-histidine

Catalog # AFH105

CAS 109425-51-6

Formula C40H33N3O4

M.W. 619.7

Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH is the histidine derivative most commonly utilized in peptide synthesis by Fmoc chemistry. The Trt group is easily removed with acid, but the trityl cation may reattach at nucleophilic sites in the resin. Using cleavae cocktails containing triisopropylsilane (TIS) or ethane dithiol will minimize this side reaction.

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