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Fmoc-D-Thr(tBu)-OH [138797-71-4]


Other Names: N-(9-fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine

Catalog # AFT205

CAS 138797-71-4

Formula C23H27NO5

M.W. 397.5







Fmoc-D-Thr(tBu)-OH, when epimerized, generates L-allo-threonine.  Fmoc-D-Thr(tBu)-OH from AAPPTec does not contain allo-threonine or D-allo-threonine.  

D-Threonine is not one of the standard proteinaceous amino acids, but it often occurs in bacterial peptides.  Chlopstatin, himastatin and AB3586C are three examples of antibiotic peptides from Strptomyces species that incorporate D-threonine residues (K. Umezawa, et al., J. Org. Chem., 2000, 65, 459-63; J. E. Lee, et al., J. Antibiot. (Tokyo), 1996, 49, 299-31; T. A. Smitka, et al., J. Antibiot. (Tokyo), 1988, 41, 726-33).

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