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Fmoc-Cys(Trt)-OH [103213-32-7]

N-Fmoc-S-trityl-L-cysteine

Other Names: Fmoc-L-Cys(Trt)-OH; N-Fmoc-S-triphenylmethyl-L-cysteine

Catalog # AFC105

CAS 103213-32-7

Formula C37H31NO4S

M.W. 585.7

Fmoc-Cys(Trt)-OH

Fmoc-Cys(Trt)-OH is the cysteine derivative most commonly utilized in solid phase peptide synthesis with Fmoc amino acids. The trityl group can be removed from the cysteine side chain with trifluoroacetic acid (TFA) leaving an unprotected thiol. Iodine may be used to remove the trityl group and subsequently form a disulfide bond (Technical Bulletin 1127). This method is useful for preparing peptides containing disulfide bridges. Fmoc-Cys(Acm)-OH may be used in conjuction with Fmoc-Cys(Trt)-OH. Like the trityl group, Iodine can remove the Acm group and oxidize the exposed thiol to disulfide.

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