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Fmoc-Asn(Trt)-OH [132388-59-1]

N-alpha-Fmoc-N-gamma-trityl-L-asparagine

Other Names: Fmoc-L-Asn(Trt)-OH; Nα-Fmoc-Nγ-triphenylmethyl-L-asparagine

Catalog # AFN105

CAS 132388-59-1

Formula C38H32N2O5

M.W. 596.67

Fmoc-Asn(Trt)-OH

Using Fmoc-Asn(Trt)-OH in peptide synthesis prevents the possibility of the amide side chain of Asn from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Asn(Trt)-OH also has better solubility properties than Fmoc-Asn-OH. Fmoc-Asn(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Asn-OH is barely soluble in dimethylformamide (DMF).

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