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Custom Peptide Libraries

Custom peptide libraries from AAPPTec are provided in 96-well plates with approximately 2 μmol of lyophilized peptide in each well. AAPPTec can synthesize peptide libraries for drug discovery, high-throughput screening, and SAR studies, including alanine scans and truncation sets. AAPPTec utilizes optimized protocols and chemistries to ensure consistent purity, quantity, and quality library-to-library and within each peptide library.

AAPPTec can incorporate most standard peptide modifications within custom peptide libraries. Standard modifications that can be incorporated are unusual amino acids, D-amino acids, C-terminal amidation, N-terminal modification, and biotin, dye or fluorescence labeling on the N-terminal or lysine side chains.

Custom libraries are typically completed in 2-3 weeks. Typical delivery consists of lyophilized peptides in 96-well titer plates, peptide location table, and MS and HPLC data. For a quotation, please complete our quotation form and in the comment box state that you are requesting a quotation on a peptide library.

Custom Peptide Library Prices

The prices below are for crude peptides without MS and HPLC data, as synthesized, 1-4 mg per well. If you need MS and/or HPLC data please complete our quotation form and in the comment box state that you are requesting such with you peptide library.

Titer Plate Number of Crude Peptides Price/Peptide
1/2 48 $29
1 96 $25
2 192  $24
4 384 $22

Custom Peptide Libraries Provided By AAPPTec

Peptide Scanning Library

Alanine Scanning libraries are most common, although scanning libraries of other amino acids have been reported. In alanine scanning libraries, each amino acid in the peptide sequence is individually replaced by alanine. Alanine scans are useful for identifying essential residues within the peptide. When an essential residue is replaced with alanine, the corresponding peptide shows markedly reduced activity.

Truncation Peptide Library

In truncation peptide libraries, the peptide sequence is systematically shortened from the N-terminal or C-terminal. Truncation libraries are useful for identifying the minimum peptide length required for activity. Truncation libraries can be useful in studying the metabolic degradation of peptide drugs.

Scrambled Peptide Library

Scrambled peptide libraries are prepared through permutation of the original peptide sequence. Scrambled libraries can provide valuable information for sequence optimization.

Combinatorial Peptide Library

Combinatorial peptide libraries, in their broadest form, contain every possible peptide of a specific length; therefore, they are useful for drug discovery and research. Combinatorial libraries are prepared by systematically substituting every amino acid at each position in the sequence. Since the number of possible peptides can become astronomical, combinatorial libraries are often constrained by strictly limiting the number of amino acids used in creating the library or limiting the number of positions that are substituted. When only a few positions are randomized, the library is called a Positional Scanning Library.

Positional Scanning Peptide Library

In positional scanning peptide libraries, every amino acid is systematically substituted into a specified position in a peptide. Positional scanning libraries are highly constrained versions of combinatorial libraries. They are useful for sequence optimization.

Overlap Peptide Library

Overlap peptide libraries are used in mapping linear epitopes. Overlap libraries are characterized by the fragment length and overlap number.

Ala Scan Library

 Alanine Scan Library

scrambled peptide library

 Scrambled Library

positional scan peptide libray

Positional Scan Library

truncation peptide library

 Truncation Library