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Boc-D-Gln(Trt)-OH [210750-95-1]


Catalog #: ABQ210

CAS #: 210750-95-1

Formula: C29H32N2O5

M.W.: 488.6





Boc-D-Gln(Trt)-OH is a glutamine derivative often utilized in Boc SPPS. The trityl protecting group improves the solubility of the Boc-D-glutamine derivative. It also protects the amide group from dehydration when the derivative is activated with dicarbodiimide. When the Boc group is removed for the next coupling, the trityl group is also removed. Since the sidechain protection is mainly required during activation and coupling of the glutamine residue, removal of the trityl group after the D-glutamine residue is coupled to the peptide is not important. The dehydration side reaction can be prevented by preactivating the amino acids or by utilizing activating reagents other than carbodiimides.

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