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One-Pot Synthesis of l-7-Iodotryptophan

The First One-Pot Synthesis of l-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other l-7-Halotryptophans DRM Smith, T Willemse, DS Gkotsi, W Schepens, BUW Maes,S Ballet , RJM Goss,  Org. Lett., 2014, 16, 2622–2625. A simple and scalable...

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New coupling reagent for solid phase peptide synthesis

3-Nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as a condensing reagent for solid-phase peptide synthesis K Saito, T Wada, Tetrahedron Letters, 2014, 55, 1991-1993. Solid-phase oligopeptide synthesis has been well developed and...

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An Iodine-Free and Directed-Disulfide-Bond-Forming Route

An Iodine-Free and Directed-Disulfide-Bond-Forming Route to Insulin Analogues F Liu, Q Liu, AR Mezo, Org. Lett., Article ASAP, Publication Date (Web): May 26, 2014 An iodine-free synthetic route to insulin analogues has been established via a directed disulfide bond...

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Lucifensins, the Insect Defensins of Biomedical Importance

Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy.                                                                                                                   V CeÅ™ovský, R Bém,  Pharmaceuticals (Basel), 2014, 7,...

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Immune regulatory activities of fowlicidin-1

Immune regulatory activities of fowlicidin-1, a cathelicidin host defense peptide.   YR Bommineni, GH Pham, LT Sunkara, M Achanta, G Zhang, Mol Immunol., 2014, 59, 55-63. Appropriate modulation of immunity is beneficial in antimicrobial therapy and vaccine...

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Neuropeptide W has anorexigenic effect

Central neuropeptide W has anorexigenic effect in rats.                                               T Naso, S Shousha, A El-Kirdasy, J Anim Physiol Anim Nutr (Berl)., 2014, 98, 228-34. Neuropeptide W (NPW) is produced in neurons located in hypothalamus, brain stem...

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Neurokinin B binds copper(I) and silver(I)

The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry: Towards a new function for the peptide in the brain.                                                                                                     ...

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Short peptides highly potent against fungus

Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans                                                                                                                      Amit Mahindra, Nitin Bagra, Nishima Wangoo, Shabana I....

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Peptoids modulate aggregation of amyloid-beta 40

Rationally designed peptoids modulate aggregation of amyloid-beta 40                    J. Phillip Turner, Tammy Lutz-Rechtin, Kelly A. Moore, Lauren Rogers, Omkar Bhave, Melissa A Moss, Shannon L Servoss, ACS Chem. Neurosci., Just Accepted Manuscript.  Publication...

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Transthyretin-Derived Peptides as β-Amyloid Inhibitors

Transthyretin-Derived Peptides as β-Amyloid Inhibitors                                      Patricia Y. Cho, Gururaj Joshi, Jeffrey A. Johnson, Regina M. Murphy, ACS Chem. Neurosci., Article ASAP                                                                        ...

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Peptidic Tool Compounds To Study the Phosphatase PTP1B

Development of Accessible Peptidic Tool Compounds To Study the Phosphatase PTP1B in Intact Cells                                                                                               Christoph Meyer, Birgit Hoeger, Koen Temmerman, Marianna...

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Chemical Synthesis of Insulin Analogs

Chemical Synthesis of Insulin Analogs through a Novel Precursor                Alexander N. Zaykov, John P. Mayer, Vasily M. Gelfanov, and Richard D. DiMarchi, ACS Chem. Biol., 2014, 9 (3), pp 683–691. Insulin remains a challenging synthetic target due in large part...

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Peptides induce mineralization and binding to TiO2

Bifunctional designed peptides induce mineralization and binding to TiO2            Anna Gitelman, Hanna Rapaport, Langmuir, 2014, 30, 4716-4724.                       Copyright © 2014 American Chemical Society A limitation of titanium implants is the rather poor...

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