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A hybrid cationic peptide exhibits salt-resistant antimicrobial activity.
A hybrid cationic peptide composed of human beta-defensin-1 and humanized theta-defensin sequences exhibits salt-resistant antimicrobial activity. Olli S, Nagaraj R, Motukupally SR., Antimicrob. Agents Chemother., 2014, Oct 27. [Epub ahead of print] We have designed...
Lixisenatide shows neuroprotective effects in a mouse model of Alzheimer’s disease.
Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease. McClean PL, Hölscher C., Neuropharmacology, 2014, 86, 241-58. Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). In...
Antimicrobial activity of trout hepcidin.
Antimicrobial activity of trout hepcidin. Alvarez CA, Guzmán F, Cárdenas C, Marshall SH, Mercado L., Fish Shellfish Immunol., 2014, 41, 93-101. Hepcidin is an antimicrobial peptide and a hormone produced mostly the liver. It is a cysteine-rich peptide with a highly...
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes. Chrudimská T, Čeřovský V, Slaninová J, Rego RO, Grubhoffer L., Dev. Comp. Immunol., 2014, 46, 165-70. Expression of the previously reported defensin of the...
Antimicrobials, stress and mutagenesis.
Antimicrobials, stress and mutagenesis. RodrÃguez-Rojas A, Makarova O, Rolff J., PLoS Pathog., 2014, 10, e1004445. Cationic antimicrobial peptides are ancient and ubiquitous immune effectors that multicellular organisms use to kill and police microbes whereas...
Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle
Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle Miller JP, Melicher MS, Schepartz A, J. Am. Chem. Soc., 2014, 136, 14726–14729. Metal ion binding is exploited by proteins in nature to catalyze reactions, bind molecules, and favor...
The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology
The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology Andreasen M, Skeby KK, Zhang S, Nielsen EH, Klausen LH, Frahm H, Christiansen G, Skrydstrup T, Mingdong Dong, Birgit Schiøtt, Daniel...
Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin.
Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin. Quintana VM, Torres NI, Wachsman MB, Sinko PJ, Castilla V, Chikindas M., J. Appl. Microbiol., 2014, 117, 1253-9. AIMS: In this study, we evaluated the antiviral activity of subtilosin,...
Vipericidins: a novel family of cathelicidin-related peptides
Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Falcao CB, de La Torre BG, Pérez-Peinado C, Barron AE, Andreu D, Rádis-Baptista G., Amino Acids., 2014, 46, 2561-71. Cathelicidins are phylogenetically...
Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom.
Solution structures and model membrane interactions of Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom. Bandyopadhyay S, Junjie RL, Lim B, Sanjeev R, Xin WY, Yee CK, Hui Melodies SM, Yow N, Sivaraman J, Chatterjee C.,...
Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin.
Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin. Yin C, Wong JH, Ng TB, Curr. Mol. Med., 2014 Oct 15. [Epub ahead of print] Lactoferricin and lactoferrampin, peptides derived from the whey protein lactoferrin, are...
Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide.
Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide. Schroeder BO, Ehmann D, Precht JC, Castillo PA, Küchler R, Berger J, Schaller M, Stange EF, Wehkamp J., Mucosal Immunol., 2014, Nov 5. [Epub ahead of print] Defensins protect human barriers from...
Laterosporulin, a Class IId Bacteriocin, Conceals Human Defensin-like Structural Module.
Intra-molecular Disulfide-Stapled Structure of Laterosporulin, a Class IId Bacteriocin, Conceals Human Defensin-like Structural Module. Singh PK, Solanki V, Sharma S, Thakur KG, Krishnan B, Korpole S., FEBS J., 2014, Oct 27. [Epub ahead of print] The growing...
Dipeptide Phe-Cys suppresses oxidative stress in cultured human hepatocytes.
Dipeptide Phe-Cys derived from in silico thermolysin-hydrolysed RuBisCO large subunit suppresses oxidative stress in cultured human hepatocytes. Je JY, Cho YS, Gong M, Udenigwe CC., Food Chem., 2015, 171, 287-91. A dipeptide (Phe-Cys) was predicted to be bioactive...
Four residues of propeptide are essential for precursor folding of nattokinase.
Four residues of propeptide are essential for precursor folding of nattokinase. Jia Y, Cao X, Deng Y, Bao W, Tang C, Ding H, Zheng Z, Zou G., Acta Biochim. Biophys. Sin (Shanghai). , 2014, 46, 957-64. Subtilisin propeptide functions as an intramolecular chaperone...
Glucagon-like peptide-1 induces formation of new elastic fibers in human cardiac fibroblasts
The anti-diabetic hormone glucagon-like peptide-1 induces formation of new elastic fibers in human cardiac fibroblasts after cross-activation of IGF-1R. Qa'aty N, Wang Y, Wang A, Mao S, Vincent M, Husain M, Hinek A., Endocrinology, 2014, Oct 29:en20141519. [Epub...
Antibacterial Peptide Derived From Fish NK-lysin
NKLP27: A Teleost NK-Lysin Peptide that Modulates Immune Response, Induces Degradation of Bacterial DNA, and Inhibits Bacterial and Viral Infection. Zhang M, Li MF, Sun L, PLoS One, 2014, 9, e106543. NK-lysin is an antimicrobial protein produced by cytotoxic T...
Indolicidin Stabilizes Duplex DNA and Prevents DNA Replication and Transcription
Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy. Ghosh A, Kar RK, Jana J, Saha A, Jana B, Krishnamoorthy J, Kumar D, Ghosh S, Chatterjee S, Bhunia A, ChemMedChem, 2014, 9, 2052-8. Indolicidin...
