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Fluorescent Amino Acid for Site-Specific Probing and Imaging of Peptide Interactions
Fluorescent Amino Acid Undergoing Excited State Intramolecular Proton Transfer for Site-Specific Probing and Imaging of Peptide Interactions Sholokh M, Zamotaiev OM, Das R, Postupalenko VY, Richert L, Dujardin D, Zaporozhets OA, Pivovarenko VG, Klymchenko AS, Mély...
Immobilized Coupling Reagents: Synthesis of Amides/Peptides
Immobilized Coupling Reagents: Synthesis of Amides/Peptides Cherkupally P, Ramesh S, de La Torre BG, Govender T, Kruger HG, Albericio F, ACS Comb. Sci., 2014 Article ASAP Copyright © 2014 American Chemical Society The primary idea of using immobilized reagents in...
Postsynthetic Modification of Unprotected Peptides via S-Tritylation Reaction
Postsynthetic Modification of Unprotected Peptides via S-Tritylation Reaction Mochizuki M, Hibino H, Nishiuchi Y, Org. Lett., 2014 Articles ASAP (As Soon As Publishable) Tritylation using trityl alcohol (Trt–OH) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is a...
Postinfection Activity of Synthetic Antimicrobial Peptides Against Stemphylium vesicarium in Pear.
Postinfection Activity of Synthetic Antimicrobial Peptides Against Stemphylium vesicarium in Pear. Puig M, Moragrega C, Ruz L, Montesinos E, Llorente I., Phytopathology, 2014, 104, 1192-200. Brown spot of pear is a fungal disease of economic importance caused by...
Dual function of a bee (Apis cerana) inhibitor cysteine knot peptide that acts as an antifungal peptide and insecticidal venom toxin.
Dual function of a bee (Apis cerana) inhibitor cysteine knot peptide that acts as an antifungal peptide and insecticidal venom toxin. Park HG, Kyung SS, Lee KS, Kim BY, Choi YS, Yoon HJ, Kwon HW, Je YH, Jin BR., Dev. Comp. Immunol., 2014, 47, 247-53. Inhibitor...
A hybrid cationic peptide exhibits salt-resistant antimicrobial activity.
A hybrid cationic peptide composed of human beta-defensin-1 and humanized theta-defensin sequences exhibits salt-resistant antimicrobial activity. Olli S, Nagaraj R, Motukupally SR., Antimicrob. Agents Chemother., 2014, Oct 27. [Epub ahead of print] We have designed...
Lixisenatide shows neuroprotective effects in a mouse model of Alzheimer’s disease.
Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease. McClean PL, Hölscher C., Neuropharmacology, 2014, 86, 241-58. Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). In...
Antimicrobial activity of trout hepcidin.
Antimicrobial activity of trout hepcidin. Alvarez CA, Guzmán F, Cárdenas C, Marshall SH, Mercado L., Fish Shellfish Immunol., 2014, 41, 93-101. Hepcidin is an antimicrobial peptide and a hormone produced mostly the liver. It is a cysteine-rich peptide with a highly...
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes. Chrudimská T, Čeřovský V, Slaninová J, Rego RO, Grubhoffer L., Dev. Comp. Immunol., 2014, 46, 165-70. Expression of the previously reported defensin of the...
Antimicrobials, stress and mutagenesis.
Antimicrobials, stress and mutagenesis. RodrÃguez-Rojas A, Makarova O, Rolff J., PLoS Pathog., 2014, 10, e1004445. Cationic antimicrobial peptides are ancient and ubiquitous immune effectors that multicellular organisms use to kill and police microbes whereas...
Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle
Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle Miller JP, Melicher MS, Schepartz A, J. Am. Chem. Soc., 2014, 136, 14726–14729. Metal ion binding is exploited by proteins in nature to catalyze reactions, bind molecules, and favor...
The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology
The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology Andreasen M, Skeby KK, Zhang S, Nielsen EH, Klausen LH, Frahm H, Christiansen G, Skrydstrup T, Mingdong Dong, Birgit Schiøtt, Daniel...
Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin.
Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin. Quintana VM, Torres NI, Wachsman MB, Sinko PJ, Castilla V, Chikindas M., J. Appl. Microbiol., 2014, 117, 1253-9. AIMS: In this study, we evaluated the antiviral activity of subtilosin,...
Vipericidins: a novel family of cathelicidin-related peptides
Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Falcao CB, de La Torre BG, Pérez-Peinado C, Barron AE, Andreu D, Rádis-Baptista G., Amino Acids., 2014, 46, 2561-71. Cathelicidins are phylogenetically...
Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom.
Solution structures and model membrane interactions of Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom. Bandyopadhyay S, Junjie RL, Lim B, Sanjeev R, Xin WY, Yee CK, Hui Melodies SM, Yow N, Sivaraman J, Chatterjee C.,...
Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin.
Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin. Yin C, Wong JH, Ng TB, Curr. Mol. Med., 2014 Oct 15. [Epub ahead of print] Lactoferricin and lactoferrampin, peptides derived from the whey protein lactoferrin, are...
Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide.
Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide. Schroeder BO, Ehmann D, Precht JC, Castillo PA, Küchler R, Berger J, Schaller M, Stange EF, Wehkamp J., Mucosal Immunol., 2014, Nov 5. [Epub ahead of print] Defensins protect human barriers from...
Laterosporulin, a Class IId Bacteriocin, Conceals Human Defensin-like Structural Module.
Intra-molecular Disulfide-Stapled Structure of Laterosporulin, a Class IId Bacteriocin, Conceals Human Defensin-like Structural Module. Singh PK, Solanki V, Sharma S, Thakur KG, Krishnan B, Korpole S., FEBS J., 2014, Oct 27. [Epub ahead of print] The growing...
