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Novel synthetic anti-fungal tripeptide effective against Candida krusei.
Novel synthetic anti-fungal tripeptide effective against Candida krusei. Gill K, Kumar S, Xess I, Dey S., Indian J Med Microbiol., 2015, 33, 110-6. INTRODUCTION: Candida species are the major fungal pathogens of humans. Among them, Candida krusei have emerged as a...
Antimicrobial Peptides with Potential for Biofilm Eradication
Antimicrobial Peptides with Potential for Biofilm Eradication: Synthesis and Structure Activity Relationship Studies of Battacin Peptides. De Zoysa GH, Cameron AJ, Hegde VV, Raghothama S, Sarojini V., J Med Chem. 2015, 58, 625-639. We report on the first chemical...
Detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15
Single-cell, real-time detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15 Choi H, Yang Z, Weisshaar JC, Proc Natl Acad Sci USA. 2015, 112, E303-E310. Antibiotics target specific biochemical mechanisms in bacteria. In response...
Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium
Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer Oliver B. Vining, Rebecca A. Medina, Edward A. Mitchell, Patrick Videau, Dong Li, Jeffrey D. Serrill, Jane X. Kelly, William H. Gerwick,Philip J. Proteau, Jane...
Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines
Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines Nathalie Lensen, Joyce Marais, and Thierry Brigaud, Org. Lett., Article ASAP, Publication Date (Web): January 6, 2015 DOI: 10.1021/ol503448w The...
A potential agent against cryptococcosis
Synthesis of a new peptide-coumarin conjugate: a potential agent against cryptococcosis Soraya Z. Ferreira , Hellem C. Carneiro , Hugo A. Lara , Rosemeire B. Alves , Jarbas M Resende ,HeloÃsa M. Oliveira , Luciana M. Silva , Daniel A Santos , and Rossimirian P....
Ht31 peptide inhibited inflammatory pain
Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice. Wang WT, Pan GQ, Zhang ZY, Suo ZW, Yang X, Hu XD, Neuropharmacology, 2015, 89, 290-7. A kinase anchoring proteins (AKAPs) assemble...
Oxytocin increases empathy to pain when adopting the other- but not the self-perspective.
Oxytocin increases empathy to pain when adopting the other- but not the self-perspective. Abu-Akel A, Palgi S, Klein E, Decety J, Shamay-Tsoory S, Soc Neurosci. 2015 Feb;10(1):7-15. There is growing evidence that the neuropeptide oxytocin (OT) facilitates various...
Identification and distribution of SIFamide in the nervous system of the desert locust Schistocerca gregaria.
Identification and distribution of SIFamide in the nervous system of the desert locust Schistocerca gregaria. Gellerer A, Franke A, Neupert S, Predel R, Zhou X, Liu S, Reiher W, Wegener C, Homberg U, J. Comp. Neurol., 2015, 523, 108-25. SIFamides are a family of...
Analgesic Properties of a Galanin Analog
Analgesic Properties of a Peripherally Acting and GalR2 Receptor-Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models. Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS, J. Pharmacol. Exp. Ther., 2015, 352, 185-93. ...
Hydroxy-tryptophan containing derivatives of tritrpticin
Hydroxy-tryptophan containing derivatives of tritrpticin: Modification of antimicrobial activity and membrane interactions. Arias M, Jensen KV, Nguyen LT, Storey DG, Vogel HJ, Biochim Biophys Acta., 2015, 1848, 277-88. Tritrpticin is...
A Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide. Zhu X, Ma Z, Wang J, Chou S, Shan A., PLoS One, 2014, 9(12), e114605. Here, we found that simple substitution of amino acids in the...
Ghrelin effects expression of several genes associated with depression-like behavior
Ghrelin effects expression of several genes associated with depression-like behavior Poretti MB, Rask-Andersen M, Kumar P, Rubiales de Barioglio S, Fiol de Cuneo M, Schiöth HB, Carlini VP, Prog Neuropsychopharmacol Biol Psychiatry, 2015, 56, 227-34. Ghrelin (Ghr) is...
A monomeric peptide triagonist corrects obesity and diabetes in rodents.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D,Seeley RJ, Bleicher K, Uhles S, Riboulet...
An ACTH4-10 peptide analog with high affinity for copper(II) ion
Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity. Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E, J Inorg Biochem. 2015, 142,...
Enhanced transdermal Peptide delivery and stability by lipid conjugation
Enhanced transdermal Peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights. Namjoshi S, Toth I, Blanchfield JT, Trotter N, Mancera RL, Benson HA., Pharm Res., 2014, 31, 3304-12. PURPOSE: Efficient...
Peptide inhibitor of cytomegalovirus infection from human hemofiltrate
A Peptide inhibitor of cytomegalovirus infection from human hemofiltrate. Borst EM, Ständker L, Wagner K, Schulz TF, Forssmann WG, Messerle M. Antimicrob Agents Chemother. 2013 Oct;57(10):4751-60. doi: 10.1128/AAC.00854-13. Epub 2013 Jul 15. Naturally occurring...
LL-37 modulates human neutrophil responses to influenza A virus.
LL-37 modulates human neutrophil responses to influenza A virus. Tripathi S, Verma A, Kim EJ, White MR, Hartshorn KL., J. Leukoc. Biol., 2014, 96, 931-8. Recent studies have shown that the human cathelicidin, LL-37, has antiviral activity against IAV in vitro and in...
