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C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells
C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. Kawabata A, Matsuzuka T, Doi C, Seiler G, Reischman J, Pickel L,...
Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Found in a Thermolysin-Treated Elastin
Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Found in a Thermolysin-Treated Elastin with Antihypertensive Activity. Sato Y, Toyoda T, Shimizu-Ibuka A, Tamura T, Kobayashi-Hattori K, Nakamura T, Arai S, Mura K., Biosci Biotechnol Biochem. DOI:...
TAPP analogs containing β(3) -homo-amino acids
TAPP analogs containing β(3) -homo-amino acids: synthesis and receptor binding. Podwysocka D, Kosson P, Lipkowski AW, Olma A., J Pept Sci. DOI: 10.1002/psc.2433 Epub ahead of print July 12, 2012. Copyright © 2012 European Peptide Society and John Wiley & Sons,...
“Customizable†Units in Di- and Tripeptides: Selective Conversion into Substituted Dehydroamino Acids
“Customizable†Units in Di- and Tripeptides: Selective Conversion into Substituted Dehydroamino Acids Carlos J. Saavedra, Alicia Boto, and Rosendo Hernández, Org. Lett., Article ASAP DOI: 10.1021/ol301676z Publication Date (Web): July 11, 2012 Copyright © 2012...
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Synthesis of cyclic gomesin
Machado, et al. recently published a paper (J. Pept. Sci. 2012, 18, 588-98) in which they report synthesized backbone cyclized analogs of gomesin, an antimicrobial peptide from the hemocytes of the Brazilian spider Acantoscurria gomesiana. They performed the backbone...
Slow Gradient HPLC for Peptide Purification
Harris, Lee and Brimble reported in the J. Pept. Sci. (J. Pept. Sci. 2012, 18(9); 549-55.) that they could purify hundreds of milligrams of peptide on a semi-preparative column in a single step by using a slow gradient of 0.1%B per minute. Their results are...
Cysteine Racemization
JH Park, et al. reported in J Pept Sci. 2012 ;18(7):442-8 that in the synthesis of Protoxin II, they saw up to 50% racemization of Cys during coupling when they used N-methylmorpholine. They could significantly reduce racemization if they used 2,4,6-collidine in...
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