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High Performance Peptide Synthesizers

High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and...

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Isoacyl Dipeptides

Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard peptide analogs...

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Adrenomedullin and Alzheimer’s Disease

Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R Martínez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated...

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Endothelin 1 and Anxiety-Like Behaviors

Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM, Mol...

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Design and Synthesis of Aphicidal Peptides

Eco-friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis and Aphicidal Activity of Novel Insect Kinin Analogs Chuan-liang Zhang, Yanyan Qv, Xiaoqing Wu, Dunlun Song, Yun Ling, and Xinling Yang, J. Agric. Food Chem., Just Accepted Manuscript...

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Macrocyclic peptide with an unusual Lys-Trp crosslink

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost, Nature Chemistry, 2015, 7, 431–437. Streptococcal bacteria use peptide signals as a...

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