Blog
Stereocontrolled Construction of (E)-2-Amino-2-butenamide
Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide Tomoya Yamashita, Takefumi Kuranaga, and Masayuki Inoue, Org. Lett., Article ASAP Publication Date (Web): April 13, 2015 Copyright © 2015...
Expanded Application of Native Chemical Ligation Using beta-Thio Phenylalanine and Desulfurization
Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry Lara R. Malins, Andrew M. Giltrap, Luke J. Dowman, and Richard J. Payne, Org. Lett., Article ASAP Publication Date (Web): April 10, 2015 Copyright © 2015 American...
Macrocyclic peptide with an unusual Lys-Trp crosslink
Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost, Nature Chemistry, 2015, 7, 431–437. Streptococcal bacteria use peptide signals as a...
A potent peptide inhibitor of α-synuclein aggregation.
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. Cheruvara H, Allen-Baume VL, Kad NM, Mason JM., J. Biol. Chem., 2015, First published on-line: January 23, 2015. DOI: 10.1074/jbc.M114.620484 Aggregation of...
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment Keith G. Davies, Brian Zimmerman, Ed Dudley,Russell P. Newton, John E. Hart, J. Exper. Biol., Published...
Anuran trypsin inhibitory peptides against Staphylococcal skin infection
Evaluation of in vivo efficacy of anuran trypsin inhibitory peptides against Staphylococcal skin infection and the impact of peptide cyclization U Malik,O. N. Silva, I. C. M. Fensterseifer, L. Y. Chan, R. J. Clark, O. L. Franco, N. L. Daly, D. J. Craik, Antimicrob....
CancerPPD: a database of anticancer peptides and proteins
CancerPPD: a database of anticancer peptides and proteins Atul Tyagi, Abhishek Tuknait, Priya Anand, Sudheer Gupta, Minakshi Sharma,Deepika Mathur, Anshika Joshi, Sandeep Singh, Ankur Gautam, Gajendra P.S. Raghava, Nucl. Acids Res. , 2015, 43, D837-D843. CancerPPD...
Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic
Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic Alessandro Gori, Ching-I A. Wang, Peta J. Harvey, K. Johan Rosengren, Rebecca F. Bhola, Maria L. Gelmi, Renato Longhi, Macdonald J. Christie, Richard J. Lewis, Paul...
Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E
Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues Motoki Murai, Takuya Kaji, Takefumi Kuranaga, Hiroshi Hamamoto, Kazuhisa Sekimizu and Masayuki Inoue, Ang. Chem. IEE, 2015, 54,...
Pachymodulin has Janus-like immunomodulatory capacities
Pachymodulin, a new functional formyl peptide receptor 2 (FPR2) peptidic ligand isolated from frog skin, has Janus-like immunomodulatory capacities Claire Lacombe, Christophe Piesse, Sandrine Sagan, Christophe Combadiere, Yvonne Rosenstein, and Constance Auvynet, J....
Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition
Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition Kentaro Takayama, Yuri Noguchi, Shin Aoki, Shota Takayama, Momoko Yoshida, Tomo Asari, Fumika Yakushiji, Shin-ichiro Nishimatsu, Yutaka Ohsawa, Fumiko Itoh, Yoichi...
Highly Angiogenic Peptide Nanofibers
Highly Angiogenic Peptide Nanofibers Vivek A. Kumar, Nichole L. Taylor, Siyu Shi,Benjamin K. Wang, Abhishek A. Jalan, Marci K. Kang, Navindee C. Wickremasinghe, and Jeffrey D. Hartgerink, ACS Nano, 2015, 9, 860-868. Major limitations of current tissue regeneration...
Haloganan: A novel antimicrobial peptide for treatment of wound infections
Haloganan: A novel antimicrobial peptide for treatment of wound infections Seo Hwa Shin, Bosung Kim, Seungmi Park, Sungho Jo, In Hee Lee, Peptides, 2014, 62, 137-143. HG1 is a Leu-rich antimicrobial peptide (AMP). Previously, the peptide was shown to lose its activity...
Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor
Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor Harveen Kaur, Paul W. R. Harris, Peter J. Little, and Margaret A. Brimble, Org. Lett., 2015, 17, 492-495. The first total synthesis of YM-280193, a cyclic depsipeptide that inhibits...
Effect of Size and N-Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7
Effect of Size and N-Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7 Filomena Guida, Monica Benincasa, Sotir Zahariev, Marco Scocchi, Federico Berti,Renato Gennaro, and Alessandro Tossi, J....
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products William M. Hewitt, Siegfried S. F. Leung, Cameron R. Pye, Alexandra R. Ponkey, Maria Bednarek, Matthew P. Jacobson, and R. Scott Lokey, J. Am. Chem. Soc., 2015, 137, 715-721. Drug...
Antidepressant-like effects of alarin
Antidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice. Wang M, Zhou W, Zhou X, Zhuang F, Chen Q, Li M, Ma T, Gu S., Behav. Brain Res., 2015, 280, 128-40. Alarin is a newly identified member of the...
Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.
Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders. Enman NM, Sabban EL, McGonigle P, Van Bockstaele EJ., Neurobiol Stress., 2015, 1, 33-43. Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many...
