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Isoacyl Dipeptides

Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard peptide analogs...

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Adrenomedullin and Alzheimer’s Disease

Adrenomedullin Expression in Alzheimer's Brain AP Fernandez, JS Masa, MA Guedan, HS Futch, R Martínez-Murillo, Curr. Alzheimer Res., 2016, 13, 428-38. Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated...

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Endothelin 1 and Anxiety-Like Behaviors

Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM, Mol...

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Design and Synthesis of Aphicidal Peptides

Eco-friendly Insecticide Discovery via Peptidomimetics: Design, Synthesis and Aphicidal Activity of Novel Insect Kinin Analogs Chuan-liang Zhang, Yanyan Qv, Xiaoqing Wu, Dunlun Song, Yun Ling, and Xinling Yang, J. Agric. Food Chem., Just Accepted Manuscript...

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Stereocontrolled Construction of (E)-2-Amino-2-butenamide

Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide Tomoya Yamashita, Takefumi Kuranaga, and Masayuki Inoue, Org. Lett., Article ASAP  Publication Date (Web): April 13, 2015  Copyright © 2015...

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Macrocyclic peptide with an unusual Lys-Trp crosslink

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink Kelsey R. Schramma, Leah B. Bushin & Mohammad R. Seyedsayamdost, Nature Chemistry, 2015, 7, 431–437. Streptococcal bacteria use peptide signals as a...

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A potent peptide inhibitor of α-synuclein aggregation.

Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. Cheruvara H, Allen-Baume VL, Kad NM, Mason JM., J. Biol. Chem., 2015, First published on-line: January 23, 2015.  DOI: 10.1074/jbc.M114.620484 Aggregation of...

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CancerPPD: a database of anticancer peptides and proteins

CancerPPD: a database of anticancer peptides and proteins Atul Tyagi, Abhishek Tuknait, Priya Anand, Sudheer Gupta, Minakshi Sharma,Deepika Mathur, Anshika Joshi, Sandeep Singh, Ankur Gautam, Gajendra P.S. Raghava, Nucl. Acids Res. , 2015, 43, D837-D843. CancerPPD...

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Pachymodulin has Janus-like immunomodulatory capacities

Pachymodulin, a new functional formyl peptide receptor 2 (FPR2) peptidic ligand isolated from frog skin, has Janus-like immunomodulatory capacities Claire Lacombe, Christophe Piesse, Sandrine Sagan, Christophe Combadiere, Yvonne Rosenstein, and Constance Auvynet, J....

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