Blog
Highly Angiogenic Peptide Nanofibers
Highly Angiogenic Peptide Nanofibers Vivek A. Kumar, Nichole L. Taylor, Siyu Shi,Benjamin K. Wang, Abhishek A. Jalan, Marci K. Kang, Navindee C. Wickremasinghe, and Jeffrey D. Hartgerink, ACS Nano, 2015, 9, 860-868. Major limitations of current tissue...
Haloganan: A novel antimicrobial peptide for treatment of wound infections
Haloganan: A novel antimicrobial peptide for treatment of wound infections Seo Hwa Shin, Bosung Kim, Seungmi Park, Sungho Jo, In Hee Lee, Peptides, 2014, 62, 137-143. HG1 is a Leu-rich antimicrobial peptide (AMP). Previously, the peptide was shown to lose its...
Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor
Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor Harveen Kaur, Paul W. R. Harris, Peter J. Little, and Margaret A. Brimble, Org. Lett., 2015, 17, 492-495. The first total synthesis of YM-280193, a cyclic depsipeptide that...
Effect of Size and N-Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7
Effect of Size and N-Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7 Filomena Guida, Monica Benincasa, Sotir Zahariev, Marco Scocchi, Federico Berti,Renato Gennaro, and Alessandro Tossi,...
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products William M. Hewitt, Siegfried S. F. Leung, Cameron R. Pye, Alexandra R. Ponkey, Maria Bednarek, Matthew P. Jacobson, and R. Scott Lokey, J. Am. Chem. Soc., 2015, 137, 715-721....
Antidepressant-like effects of alarin
Antidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice. Wang M, Zhou W, Zhou X, Zhuang F, Chen Q, Li M, Ma T, Gu S., Behav. Brain Res., 2015, 280, 128-40. Alarin is a newly identified member of...
Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.
Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders. Enman NM, Sabban EL, McGonigle P, Van Bockstaele EJ., Neurobiol Stress., 2015, 1, 33-43. Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many...
Identification and Functional Analysis of a Novel Tryptophyllin Peptide from the Skin of the Red-eye Leaf Frog, Agalychnis callidryas.
Identification and Functional Analysis of a Novel Tryptophyllin Peptide from the Skin of the Red-eye Leaf Frog, Agalychnis callidryas. Wang R, Zhou Y, Chen T, Zhou M, Wang L, Shaw C., Int J Biol Sci., 2015, 11, 209-19. Amphibian skin has proved repeatedly to...
Prevention of measles virus infection by intranasal delivery of fusion inhibitor peptides.
Prevention of measles virus infection by intranasal delivery of fusion inhibitor peptides. Mathieu C, Huey D, Jurgens E, Welsch JC, DeVito I, Talekar A, Horvat B, Niewiesk S, Moscona A, Porotto M., J Virol., 2015, 89, 1143-55. Measles virus (MV) infection...
α,β-Dehydroamino acids in naturally occurring peptides
α,β-Dehydroamino acids in naturally occurring peptides Siodłak D., Amino Acids., 2015, 47, 1-17. α,β-Dehydroamino acids are naturally occurring non-coded amino acids, found primarily in peptides. The review focuses on the type of α,β-dehydroamino acids, the...
Fungicidal mechanisms of the antimicrobial peptide Bac8c.
Fungicidal mechanisms of the antimicrobial peptide Bac8c. Lee W, Lee DG., Biochim Biophys Acta., 2015, 1848, 673-9. Bac8c (RIWVIWRR-NH2) is an analogue peptide derived through complete substitution analysis of the linear bovine host defense peptide variant...
Novel synthetic anti-fungal tripeptide effective against Candida krusei.
Novel synthetic anti-fungal tripeptide effective against Candida krusei. Gill K, Kumar S, Xess I, Dey S., Indian J Med Microbiol., 2015, 33, 110-6. INTRODUCTION: Candida species are the major fungal pathogens of humans. Among them, Candida krusei have emerged as a...
Antimicrobial Peptides with Potential for Biofilm Eradication
Antimicrobial Peptides with Potential for Biofilm Eradication: Synthesis and Structure Activity Relationship Studies of Battacin Peptides. De Zoysa GH, Cameron AJ, Hegde VV, Raghothama S, Sarojini V., J Med Chem. 2015, 58, 625-639. We report on the first...
Detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15
Single-cell, real-time detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15 Choi H, Yang Z, Weisshaar JC, Proc Natl Acad Sci USA. 2015, 112, E303-E310. Antibiotics target specific biochemical mechanisms in bacteria. In...
Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium
Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer Oliver B. Vining, Rebecca A. Medina, Edward A. Mitchell, Patrick Videau, Dong Li, Jeffrey D. Serrill, Jane X. Kelly, William H. Gerwick,Philip J....
Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines
Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines Nathalie Lensen, Joyce Marais, and Thierry Brigaud, Org. Lett., Article ASAP, Publication Date (Web): January 6, 2015   DOI: 10.1021/ol503448w The...
A potential agent against cryptococcosis
Synthesis of a new peptide-coumarin conjugate: a potential agent against cryptococcosis Soraya Z. Ferreira , Hellem C. Carneiro , Hugo A. Lara , Rosemeire B. Alves , Jarbas M Resende ,HeloÃsa M. Oliveira , Luciana M. Silva , Daniel A Santos ,...
Ht31 peptide inhibited inflammatory pain
Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice. Wang WT, Pan GQ, Zhang ZY, Suo ZW, Yang X, Hu XD, Neuropharmacology, 2015, 89, 290-7. A kinase anchoring proteins (AKAPs)...
