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Effects of Lipidation on a Short Antimicrobial Peptide

H. Bauke Albada, et al. have just reported (ACS Med. Chem. Lett., Just Accepted Manuscript DOI: 10.1021/ml300148v) that adding lipids attached to the sidechain of a lysine residue at the N- or C-terminal of the short antimicrobial peptide (Arg-Trp)3 significantly...

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Self-assembled Peptide Nanofibers

K. Tomizaki et al. recently published a report (Langmuir, Article ASAP, DOI: 10.1021/la301745x) about two short peptides that self-assemble into nanofibers.  They used the nanofibers as templates for forming and aligning ZnO particles at room temperature.   These...

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Detection of Highly Curved Membrane Surfaces

Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I J. P. Saludes, L. A. Morton, N. Ghosh, L. A. Beninson, E. R. Chapman, M. Fleshner, H. Yin, ACS Chem. Biol., Articles ASAP (As Soon As Publishable) DOI: 10.1021/cb3002705...

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TAPP analogs containing β(3) -homo-amino acids

TAPP analogs containing β(3) -homo-amino acids: synthesis and receptor binding. Podwysocka D, Kosson P, Lipkowski AW, Olma A., J Pept Sci. DOI: 10.1002/psc.2433 Epub ahead of print July 12, 2012. Copyright © 2012 European Peptide Society and John Wiley & Sons,...

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Synthesis of cyclic gomesin

Machado, et al. recently published a paper (J. Pept. Sci. 2012, 18, 588-98) in which they report synthesized backbone cyclized analogs of gomesin, an antimicrobial peptide from the hemocytes of the Brazilian spider Acantoscurria gomesiana.  They performed the backbone...

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Slow Gradient HPLC for Peptide Purification

Harris, Lee and Brimble reported in the J. Pept. Sci. (J. Pept. Sci. 2012, 18(9); 549-55.)  that they could purify hundreds of milligrams of peptide on a semi-preparative column in a single step by using a slow gradient of 0.1%B per minute. Their results are...

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Cysteine Racemization

JH Park, et al. reported in J Pept Sci. 2012 ;18(7):442-8 that in the synthesis of Protoxin II, they saw up to 50% racemization of Cys during coupling when they used N-methylmorpholine.  They could significantly reduce racemization if they used 2,4,6-collidine in...

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Welcome to Peptide Central where you can ask questions relating to peptides and peptide synthesis, read recent reports about peptides and share your experience with other peptide users and peptide preparers.

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