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Antimicrobial Peptides Effective Against Multidrug-Resistant Stain of Mycobacterium tuberculosis
Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis. Rivas-Santiago B, Rivas Santiago CE, Castañeda-Delgado JE, León-Contreras JC, Hancock RE, Hernandez-Pando R., Int J Antimicrob Agents. 2012 Nov...
Novel Peptide Targets Non-Small Cell Lung Cancer
A novel peptide (Thx) homing to non-small cell lung cancer identified by ex vivo phage display. Koivistoinen A, Ilonen II, Punakivi K, Räsänen JV, Helin H, Sihvo EI, Bergman M, Salo JA., Clin Transl Oncol. 2012 Nov 10. doi: 10.1007/s12094-012-0959-z [Epub ahead of...
Drug conjugated with EGF receptor-binding peptide targets drug resistant colon cancer cells
Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells. Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z., Br J Pharmacol. 2012 Nov 12. doi:...
Identification of putative receptors for cancer-binding peptides
High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis. Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY, Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE., Integr Biol (Camb)....
Protected: Tumor-Penetrating Peptide Designed
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Smac Peptide enhances TRAIL- or paclitaxel-induced inhibition of cell growth in ovarian cancer cells
Smac peptide potentiates TRAIL- or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo. Mao HL, Pang Y, Zhang X, Yang F, Zheng J, Wang Y, Liu P., Oncol Rep. 2012 Nov 9. doi: 10.3892/or.2012.2132. [Epub ahead of print] Second mitochondria-derived...
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin. Luo X, Jiang Q, Song G, Liu YL, Xu ZG, Guo ZY., FEBS J. 2012, 279, 3166-75. doi: 10.1111/j.1742-4658.2012.08695.x Hepcidin is a small...
Positional effects of click cyclization on β-hairpin structure, stability, and function.
Positional effects of click cyclization on β-hairpin structure, stability, and function. Park JH, Waters ML., Org Biomol Chem. 2012, Oct 15. [Epub ahead of print] DOI: 10.1039/C2OB26445E The use of the copper(i)-assisted azide-alkyne cycloaddition (CuAAC, or "click"...
Protected: Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins
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A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD., J Clin Invest. 2012, 122, 2018-31. doi: 10.1172/JCI46231. Cancer...
Stapled Peptide that Overcomes MCL-1 Dependent Leukemia Cell Survival
A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival. Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD., Chem Biol. 2012, 19, 1175-86. doi:...
Stapled Peptide Directly Targets β-Catenin
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL., Proc Natl Acad Sci U S A. 2012, 109, 17942-7. doi: 10.1073/pnas.1208396109. Aberrant activation of signaling by the Wnt...
Multi-Leu Peptide Inhibitor Exhibits Antiproliferative Effects on Prostate Cancer Cells
The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 And Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells Christine Levesque , Martin Fugère , Anna Kwiatkowska , Frédéric Couture , Roxane Desjardins , Sophie Routhier , Philippe Moussette...
Azidohomoalanine as a vibrational label in 2D IR spectroscopy
Ligand Binding Studied by 2D IR Spectroscopy Using the Azidohomoalanine Label Robbert Bloem , Klemens Koziol , Steven A. Waldauer , Brigitte Buchli , Reto Walser , Brighton Samatanga , Ilian Jelesarov , and Peter Hamm J. Phys. Chem. B, Just Accepted Manuscript DOI:...
Anti-fatigue peptides from loach protein hydrolysates
The anti-fatigue activities of loach protein hydrolysates with different antioxidant activities Lijun You , Jiaoyan Ren , Bao Yang , Joe Regenstein , and Mouming Zhao J. Agric. Food Chem., Just Accepted Manuscript DOI: 10.1021/jf3037825 Publication Date (Web):...
Peptide derived from human placenta growth factor-1 inhibits ocular Neovascularization
Inhibition of ocular neovascularization by a novel peptide derived from human placenta growth factor-1. Zheng Y, Gu Q, Xu X. Acta Ophthalmol. 2012 Nov;90(7):e512-23. doi: 10.1111/j.1755-3768.2012.02476.x. Epub 2012 Sep 20. To evaluate the effect of ZY1, a novel...
Quantum Dots
Designed Short RGD Peptides for One-Pot Aqueous Synthesis of Integrin-binding CdTe and CdZnTe Quantum Dots. He H, Feng M, Hu J, Chen C, Wang J, Wang X, Xu H, Lu JR. ACS Appl Mater Interfaces. 2012 Oct 29. [Epub ahead of print] DOI: 10.1021/am3020108 We have designed a...
New Histidine Derivative for Fmoc SPPS
Synthesis and application of N(α) -Fmoc-N(π) -4-methoxybenzyloxymethylhistidine in solid phase peptide synthesis. Hibino H, Miki Y, Nishiuchi Y. J Pept Sci. 2012 Oct 30. doi: 10.1002/psc.2464. [Epub ahead of print] The 4-methoxybenzyloxymethyl (MBom) group was...
