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Prospects in the Total Synthesis of Protein Therapeutics

Prospects in the Total Synthesis of Protein Therapeutics Justin M. Chalker Chem. Biol. Drug Design, 2013, 81, 122–135 DOI: 10.1111/cbdd.12007 Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success...

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The Future of Peptide-based Drugs

The Future of Peptide-based Drugs David J. Craik, David P. Fairlie, Spiros Liras, David Price Chem. Biol. Drug Design, 2013, 81, 136–147. DOI: 10.1111/cbdd.12055 The suite of currently used drugs can be divided into two categories – traditional ‘small...

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Antimicrobial peptides from scorpion venom

A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Nie Y, Zeng XC, Yang Y, Luo F, Luo X, Wu S, Zhang L, Zhou J. Peptides. 2012, 38, 389-94. doi: 10.1016/j.peptides.2012.09.012. The venom peptides from the scorpion Heterometrus spinifer...

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Gene delivery using peptide carriers

Rapid and efficient gene delivery into plant cells using designed peptide carriers. Manoj Kumar Lakshmanan , Yutaka Kodama , Takeshi Yoshizumi , Kumar Sudesh , and Keiji Numata Biomacromolecules, Just Accepted Manuscript DOI: 10.1021/bm301275g Publication Date (Web):...

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Novel Peptide Targets Non-Small Cell Lung Cancer

A novel peptide (Thx) homing to non-small cell lung cancer identified by ex vivo phage display. Koivistoinen A, Ilonen II, Punakivi K, Räsänen JV, Helin H, Sihvo EI, Bergman M, Salo JA., Clin Transl Oncol. 2012 Nov 10. doi: 10.1007/s12094-012-0959-z [Epub ahead of...

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Stapled Peptide Directly Targets β-Catenin

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL., Proc Natl Acad Sci U S A. 2012, 109, 17942-7. doi: 10.1073/pnas.1208396109. Aberrant activation of signaling by the Wnt...

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