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Prospects in the Total Synthesis of Protein Therapeutics
Prospects in the Total Synthesis of Protein Therapeutics Justin M. Chalker Chem. Biol. Drug Design, 2013, 81, 122–135 DOI: 10.1111/cbdd.12007 Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success...
The Future of Peptide-based Drugs
The Future of Peptide-based Drugs David J. Craik, David P. Fairlie, Spiros Liras, David Price Chem. Biol. Drug Design, 2013, 81, 136–147. DOI: 10.1111/cbdd.12055 The suite of currently used drugs can be divided into two categories – traditional ‘small...
Antimicrobial peptides from scorpion venom
A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Nie Y, Zeng XC, Yang Y, Luo F, Luo X, Wu S, Zhang L, Zhou J. Peptides. 2012, 38, 389-94. doi: 10.1016/j.peptides.2012.09.012. The venom peptides from the scorpion Heterometrus spinifer...
Gene delivery using peptide carriers
Rapid and efficient gene delivery into plant cells using designed peptide carriers. Manoj Kumar Lakshmanan , Yutaka Kodama , Takeshi Yoshizumi , Kumar Sudesh , and Keiji Numata Biomacromolecules, Just Accepted Manuscript DOI: 10.1021/bm301275g Publication Date (Web):...
Antibacterial and leishmanicidal activities of temporin-SHd
Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide. Abbassi F, Raja Z, Oury B, Gazanion E, Piesse C, Sereno D, Nicolas P, Foulon T, Ladram A., Biochimie. 2012 Oct 29. doi: 10.1016/j.biochi.2012.10.015. [Epub ahead...
Retro-Inverso Version of Catestatin Shows Prolonged Efficacy in Mouse Model of Hypertension
Novel Peptide Isomer Strategy for Stable Inhibition of Catecholamine Release: Application to Hypertension. Biswas N, Gayen J, Mahata M, Su Y, Mahata SK, O'Connor DT., Hypertension. 2012, 60(6), 1552-1559. doi: 10.1161/HYPERTENSIONAHA.112.202127 Epub 2012 Nov 5....
Antimicrobial Peptides Effective Against Multidrug-Resistant Stain of Mycobacterium tuberculosis
Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis. Rivas-Santiago B, Rivas Santiago CE, Castañeda-Delgado JE, León-Contreras JC, Hancock RE, Hernandez-Pando R., Int J Antimicrob Agents. 2012 Nov...
Novel Peptide Targets Non-Small Cell Lung Cancer
A novel peptide (Thx) homing to non-small cell lung cancer identified by ex vivo phage display. Koivistoinen A, Ilonen II, Punakivi K, Räsänen JV, Helin H, Sihvo EI, Bergman M, Salo JA., Clin Transl Oncol. 2012 Nov 10. doi: 10.1007/s12094-012-0959-z [Epub ahead of...
Drug conjugated with EGF receptor-binding peptide targets drug resistant colon cancer cells
Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells. Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z., Br J Pharmacol. 2012 Nov 12. doi:...
Identification of putative receptors for cancer-binding peptides
High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis. Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY, Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE., Integr Biol (Camb)....
Protected: Tumor-Penetrating Peptide Designed
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Smac Peptide enhances TRAIL- or paclitaxel-induced inhibition of cell growth in ovarian cancer cells
Smac peptide potentiates TRAIL- or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo. Mao HL, Pang Y, Zhang X, Yang F, Zheng J, Wang Y, Liu P., Oncol Rep. 2012 Nov 9. doi: 10.3892/or.2012.2132. [Epub ahead of print] Second mitochondria-derived...
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.
Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin. Luo X, Jiang Q, Song G, Liu YL, Xu ZG, Guo ZY., FEBS J. 2012, 279, 3166-75. doi: 10.1111/j.1742-4658.2012.08695.x Hepcidin is a small...
Positional effects of click cyclization on β-hairpin structure, stability, and function.
Positional effects of click cyclization on β-hairpin structure, stability, and function. Park JH, Waters ML., Org Biomol Chem. 2012, Oct 15. [Epub ahead of print] DOI: 10.1039/C2OB26445E The use of the copper(i)-assisted azide-alkyne cycloaddition (CuAAC, or "click"...
Protected: Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins
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A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD., J Clin Invest. 2012, 122, 2018-31. doi: 10.1172/JCI46231. Cancer...
Stapled Peptide that Overcomes MCL-1 Dependent Leukemia Cell Survival
A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival. Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD., Chem Biol. 2012, 19, 1175-86. doi:...
Stapled Peptide Directly Targets β-Catenin
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL., Proc Natl Acad Sci U S A. 2012, 109, 17942-7. doi: 10.1073/pnas.1208396109. Aberrant activation of signaling by the Wnt...
